The piglet as a model for B cell and immune system development.
The piglet as a model for B cell and immune system development.
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DOI：
10.1016/j.vetimm.2008.10.321
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发表时间：
2009-03-15
影响因子：
1.8
通讯作者：
Ramsoondar J
中科院分区：
文献类型：
--
作者：
Butler JE;Lager KM;Splichal I;Francis D;Kacskovics I;Sinkora M;Wertz N;Sun J;Zhao Y;Brown WR;DeWald R;Dierks S;Muyldermans S;Lunney JK;McCray PB;Rogers CS;Welsh MJ;Navarro P;Klobasa F;Habe F;Ramsoondar J
识别所有物种疾病的因素的能力取决于将环境因素与内在因素分开的能力。这对于研究新生儿适应性免疫反应的发展尤为重要。对实验室啮齿动物或灵长类动物的研究一直不明确，因为在哺乳动物中，环境或母体因素对新生儿的影响都无法控制：（i）在子宫内传递潜在的母体免疫调节因子，（ii）是人工的，出生后不能在没有母亲的情况下饲养。采用新生仔猪模型可以解决这些问题。然而，它的代价是必须首先描述猪的免疫系统及其发展。本文综述了猪B细胞系统，特别是在胎儿研究和新生仔猪中用于其表征的方法。理解这些程序对解释所获得的数据很重要。对新生仔猪的研究（a）提供了关于适应性免疫系统发育的有价值信息，（B）导致进化生物学的重要进展，（c）帮助我们理解被动免疫，（d）提供了利用猪解决兽医和生物医学研究和免疫治疗中特定问题的机会。本文综述了仔猪作为抗体库开发模型的发展历史，从而为指导未来的研究提供了一个框架。
The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.
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影响因子：
3.1
作者：
Brockmeier, SL;Register, KB;Kunkle, RA
通讯作者：
Kunkle, RA
影响因子：
1.8
作者：
Boersma, WJA;Zwart, RJ;Bianchi, ATJ
通讯作者：
Bianchi, ATJ
影响因子：
3.5
作者：
BUTLER, JE;MAXWELL, CF
通讯作者：
MAXWELL, CF
影响因子：
1.8
作者：
BIANCHI, ATJ;ZWART, RJ;MOONENLEUSEN, HWM
通讯作者：
MOONENLEUSEN, HWM
影响因子：
3.6
作者：
BROWN, WR;BUTLER, JE
通讯作者：
BUTLER, JE