Microspheres with 2D rGO/Alginate Matrix for Unusual Prolonged Release of Cefotaxime.
Microspheres with 2D rGO/Alginate Matrix for Unusual Prolonged Release of Cefotaxime.
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DOI：
10.3390/nano13091527
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发表时间：
2023-05-01
期刊：
影响因子：
--
通讯作者：
Ibrahim MA
中科院分区：
文献类型：
--
作者：
Gomaa I;Emam MH;Wassel AR;Ashraf K;Hussan S;Kalil H;Bayachou M;Ibrahim MA
还原氧化石墨烯（rGO）和可生物降解的天然聚合物海藻酸钠之间的协同相互作用被开发以产生在表面具有突出的尖刺特征的独特微球（尖刺微球），其充当高效抗生素头孢噻肟的超级封装和持续释放系统。以氯化钙为交联剂，制备了海藻酸钠（Alg）、海藻酸钠-头孢噻肟（Alg-CTX）和海藻酸钠-头孢噻肟-还原石墨烯（Alg-CTX-rGO）复合微球。采用场发射扫描电子显微镜（FESEM），傅里叶变换红外（FT-IR）光谱，和X-射线衍射，其特征在于微球，以研究其孔隙，粗糙度，表面形貌，官能团，相形成，纯度和结构特性。采用膜扩散法测定了头孢噻肟钠微球的体外释药特性。采用Muller-Hinton琼脂扩散法研究了CTX溶液、Alg微球、Alg-CTX微球和Alg-CTX-rGO微球对革兰氏阴性菌（大肠杆菌）的抗菌活性。所制备的样品表现出优异的结果，表明它们具有增强抗生素递送的潜力。结果表明微球2D rGO/藻酸盐基质具有增强头孢噻肟递送的潜力，具有不寻常的延长释放曲线。
A synergistic interaction between reduced graphene oxide (rGO) and a biodegradable natural polymer, sodium alginate, was developed to create unique microspheres with protruding spiky features at the surface (spiky microspheres) that act as a super encapsulation and sustained release system for the highly effective antibiotic cefotaxime. Three forms of microspheres, namely alginate (Alg), alginate-cefotaxime (Alg-CTX), and alginate-cefotaxime-reduced graphene (Alg-CTX-rGO) composites, were prepared using calcium chloride as a cross-linking agent. The microspheres were characterized using field emission scanning electron microscopy (FESEM), Fourier-transform infrared (FT-IR) spectroscopy, and X-ray diffraction to investigate their pores, roughness, surface morphology, functional groups, phase formation, purity, and structural properties. The membrane diffusion method was employed to determine the release profile of Cefotaxime from the fabricated microspheres. The antibacterial activities of CTX solution, Alg microspheres, Alg-CTX microspheres, and Alg-CTX-rGO microspheres were investigated against gram-negative bacteria (Escherichia coli) using the agar diffusion method on Muller–Hinton agar. The prepared samples exhibited excellent results, suggesting their potential for enhanced antibiotic delivery. The results demonstrated the potential of the microsphere 2D rGO/alginate matrix for enhancing cefotaxime delivery with an unusual, prolonged release profile.
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影响因子：
0.8
作者：
Baikin, A. S.;Kaplan, M. A.;Sevostyanov, M. A.
通讯作者：
Sevostyanov, M. A.
DOI：
10.1016/j.ijantimicag.2022.106543
发表时间：
2022-04-10
影响因子：
10.8
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影响因子：
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作者：
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通讯作者：
Borysiak, Slawomir