Cefotaxime Loaded Polycaprolactone Based Polymeric Nanoparticles with Antifouling Properties for In-Vitro Drug Release Applications.
Cefotaxime Loaded Polycaprolactone Based Polymeric Nanoparticles with Antifouling Properties for In-Vitro Drug Release Applications.
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DOI：
10.3390/polym13132180
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发表时间：
2021-06-30
期刊：
影响因子：
5
通讯作者：
Irshad S
中科院分区：
文献类型：
--
作者：
Javaid S;Ahmad NM;Mahmood A;Nasir H;Iqbal M;Ahmad N;Irshad S
本研究的目的是实现治疗剂的成功包封，以实现生物医学应用方面的功能。考虑到纳米技术，通过优化各种工艺参数，使用纳米沉淀技术制备载药聚己内酯（PCL）基纳米粒。研究了所得纳米制剂的体外药物释放和生物相容性应用。制备的颗粒的表面形貌和表面性能进行了表征。优化的空白和载药纳米颗粒的平均尺寸分别为200 nm和216 nm，相关电荷分别为-16.8 mV和-11.2 mV。体外释药研究表明，在pH值为5.5和7.4时，药物具有缓释作用，对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌均有抗菌活性。将优化的聚合物载药纳米颗粒F-25对两种菌株的抑制区与纯药物进行比较。与纯药物相比，可生物降解聚合物纳米颗粒中抗生素的逐渐pH响应性释放可以显着增加药物的效率和药代动力学。所获得的数据显著地注意到，所得的纳米封装的功能性可能是局部药物递送系统和皮肤应用的有希望的候选者。
The objective of the present study was to achieve the successful encapsulation of a therapeutic agent to achieve antifouling functionality regarding biomedical applications. Considering nanotechnology, drug-loaded polycaprolactone (PCL)-based nanoparticles were prepared using a nano-precipitation technique by optimizing various process parameters. The resultant nano-formulations were investigated for in vitro drug release and antifouling applications. The prepared particles were characterized in terms of surface morphology and surface properties. Optimized blank and drug-loaded nanoparticles had an average size of 200 nm and 216 nm, respectively, with associated charges of −16.8 mV and −11.2 mV. Studies of the in vitro release of drug were carried out, which showed sustained release at two different pH, 5.5 and 7.4 Antifouling activity was observed against two bacterial strains, Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The zone of inhibition of the optimized polymeric drug-loaded nanoparticle F-25 against both strains were compared with the pure drug. The gradual pH-responsive release of antibiotics from the biodegradable polymeric nanoparticles could significantly increase the efficiency and pharmacokinetics of the drug as compared to the pure drug. The acquired data significantly noted that the resultant nano-encapsulation of antifouling functionality could be a promising candidate for topical drug delivery systems and skin applications.
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影响因子：
2.6
作者：
Bakre, Lateef G.;Sarvaiya, Jayrajsinh I.;Agrawal, Yadvendra K.
通讯作者：
Agrawal, Yadvendra K.
影响因子：
6
作者：
Kemala, Tetty;Budianto, Emil;Soegiyono, Bambang
通讯作者：
Soegiyono, Bambang
影响因子：
5.5
作者：
Ebrahimi, Sahar;Farhadian, Nafiseh;Ebrahimi, Mohsen
通讯作者：
Ebrahimi, Mohsen
DOI：
10.1002/wnan.1282
发表时间：
2014-11
影响因子：
8.6
作者：
Gao, Weiwei;Thamphiwatana, Soracha;Angsantikul, Pavimol;Zhang, Liangfang
通讯作者：
Zhang, Liangfang
影响因子：
2.3
作者：
Baietto L;Corcione S;Pacini G;Perri GD;D'Avolio A;De Rosa FG
通讯作者：
De Rosa FG