Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus radiofrequency ablation treatment response (with videos).
Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus radiofrequency ablation treatment response (with videos).
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使用内窥镜三维光学相干断层扫描观察到的结构标记与巴雷特食管射频消融治疗反应相关（带视频）。
DOI：
10.1016/j.gie.2012.05.024
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发表时间：
2012-12
影响因子：
7.7
通讯作者：
Mashimo H
中科院分区：
文献类型：
--
作者：
Tsai TH;Zhou C;Tao YK;Lee HC;Ahsen OO;Figueiredo M;Kirtane T;Adler DC;Schmitt JM;Huang Q;Fujimoto JG;Mashimo H
射频消融（RFA）可有效治疗巴雷特食管（BE），但通常需要数月内多次内镜检查才能达到完全缓解。使用三维光学相干断层扫描（3D-OCT）识别与治疗反应相关的结构标志物。横截面。单一教学医院。32名男性和1名女性白人短节段BE（<3 cm）接受RFA治疗。患者接受局灶性RFA治疗，并在RFA治疗前和治疗后立即在胃食管交界处进行3D-OCT。患者在6-8周后用标准内窥镜重新检查，如果没有明显的BE，则进行活检以排除BE。使用3D-OCT确定RFA前BE上皮的厚度和RFA后即刻残留腺体样结构的存在。随访时，肠上皮化生（CE-IM）完全根除患者的BE粘膜明显薄于未达到CE-IM的患者[257±60μm vs. 403±86μm，p<0.0001]。根据受试者-操作者特征得出的333μm阈值厚度对应于预测随访时BE存在的92.3%灵敏度、85%特异性和87.9%准确性。RFA后即刻OCT可见腺体的存在也与随访时残留BE的存在相关（灵敏度为83.3%，特异性为95%，准确性为90.6%）。单中心、横断面研究，仅检查短节段BE患者。RFA治疗期间BE厚度和残留腺体的3D-OCT评估与治疗反应相关。3D-OCT可以预测RFA的反应或在未来做出实时RFA再治疗决策。
Radiofrequency ablation (RFA) is effective for treating Barrett's esophagus (BE) but often involves multiple endoscopy sessions over several months to achieve complete response. Identify structural markers using three-dimensional optical coherence tomography (3D-OCT) that correlate with treatment response. Cross-sectional. Single teaching hospital. Thirty-two male and one female Caucasians with short-segment BE (<3cm) undergoing RFA treatment. Patients were treated with focal RFA and 3D-OCT was performed at the gastroesophageal junction before and immediately after the RFA treatment. Patients were re-examined with standard endoscopy 6-8 weeks later and biopsied to rule out BE if not visibly evident. The thickness of BE epithelium before RFA and the presence of residual-gland-like structures immediately after RFA were determined using 3D-OCT. The presence of BE at follow-up was assessed endoscopically. BE mucosa was significantly thinner in patients who achieved complete eradication of intestinal metaplasia (CE-IM) than in patients who did not achieve CE-IM at follow-up [257±60μm vs. 403±86μm, p<0.0001]. A threshold thickness of 333μm derived from receiver-operator characteristics corresponds to a 92.3% sensitivity, 85% specificity and 87.9% accuracy in predicting the presence of BE at follow-up. The presence of OCT-visible glands immediately after RFA also correlated with the presence residual BE at follow-up (83.3% Sensitivity, 95% specificity, and 90.6% accuracy). Single center, cross sectional study and only patients with short-segment BE were examined. 3D-OCT assessment of BE thickness and residual glands during RFA sessions correlated with treatment response. 3D-OCT may predict response to RFA or make real-time RFA retreatment decisions in the future.
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影响因子：
120.7
作者：
Spechler, SJ;Lee, E;Williford, W
通讯作者：
Williford, W
影响因子：
158.5
作者：
Shaheen, Nicholas J.;Sharma, Prateek;Lightdale, Charles J.
通讯作者：
Lightdale, Charles J.
影响因子：
7.7
作者：
Isenberg, G;Sivak, MV;Rollins, A
通讯作者：
Rollins, A
DOI：
10.1016/s1542-3565(05)00256-9
发表时间：
2005-07-01
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Evans, John A;Nishioka, Norman S
通讯作者：
Nishioka, Norman S
DOI：
10.1016/s1052-5157(03)00044-8
发表时间：
2003-07-01
影响因子：
--
作者：
Johnston, Mark H
通讯作者：
Johnston, Mark H