MRI biosensors: a short primer.
MRI biosensors: a short primer.
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DOI：
10.1002/jmri.24298
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发表时间：
2013-09
影响因子：
4.4
通讯作者：
Louie, Angelique
中科院分区：
文献类型：
--
作者：
Louie, Angelique
大约20年前，随着第一种可激活的造影剂的开发，人们对磁共振成像（MRI）造影剂用于生物功能分子成像的兴趣激增，这种造影剂可以作为生物传感器，并根据特定的生物活性“开启”。这个简短的教程，基于2011年ISMRM会议的一个短期课程讲座，概述了控制生物传感造影剂设计的基本原则。我们描述了通过磁共振成像（MRI）造影剂可以制成T1和T2类型造影剂的传感器的机制。可以与造影剂相互作用的生物活性的例子，从最近的文献中使用具体的例子进行讨论，以说明已用于实现活化的主要作用机制。磁共振传感器pH，离子结合，酶裂解，氧化还原提出。这篇文章并不是一个详尽的回顾，而是一个说明性的入门来解释如何激活可以实现MRI造影剂。化学交换饱和转移（CEST）不包括在内，因为这些试剂已在单独的讲座中介绍。
Interest in Magnetic Resonance Imaging (MRI) contrast agents for molecular imaging of biological function experienced a surge of excitement approximately 20 years ago with the development of the first activatable contrast agents that could act as biosensors and turn “on” in response to a specific biological activity. This brief tutorial, based on a short course lecture from the 2011 ISMRM meeting, provides an overview of underlying principles governing the design of biosensing contrast agents. We describe mechanisms by which a magnetic resonance imaging (MRI) contrast agent can be made into a sensor for both T1 and T2 types contrast agents. Examples of biological activities that can interact with a contrast agent are discussed using specific examples from the recent literature to illustrate the primary mechanisms of action that have been utilized to achieve activation. MRI sensors for pH, ion binding, enzyme cleavage, and oxidation-reduction are presented. This article is not meant to be an exhaustive review, but an illustrative primer to explain how activation can be achieved for an MRI contrast agent. Chemical exchange saturation transfer (CEST) is not covered as these agents were covered in a separate lecture.
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