Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study.
Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study.
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DOI：
10.1016/j.schres.2015.01.037
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发表时间：
2015-03
影响因子：
4.5
通讯作者：
Kubicki, Marek
中科院分区：
文献类型：
--
作者：
Kikinis, Zora;Fitzsimmons, Jennifer;Dunn, Chandler;Mai-Anh Vu;Makris, Nikos;Bouix, Sylvain;Goldstein, Jill M.;Mesholam-Gately, Raquelle I.;Petryshen, Tracey;del Re, Elisabetta C.;Wojcik, Joanne;Seidman, Larry J.;Kubicki, Marek
关键词：
前连合(AC)是连接对侧颞叶和眶前区的重要的大脑半球间通路。AC的作用尚不清楚，尽管有报道称慢性精神分裂症患者的这一白质束异常。然而，尚不清楚在疾病的早期阶段是否存在AC的变化。对17例首发精神分裂症(FESZ)患者和20例健康对照进行弥散磁共振成像(DMRI)。AC采用流线型牵引术重建。DMRI测量包括分数各向异性(FA)、轨迹、轴向弥散系数(AD)和径向弥散系数(RD)，以评估AC的微结构变化。FESZ的FA减少，TRACE和RD增加。AD没有显示不同组之间的差异。观察到的这些dMRI指标的变化，即FA的减少，TRACE和RD的增加，而AD没有变化，可能指向这个白质束的髓鞘异常，并提供了精神分裂症早期存在的白质病理的证据。
The Anterior Commissure (AC) is an important interhemispheric pathway that connects contralateral temporal lobes and orbitofrontal areas. The role of the AC is not yet well understood, although abnormalities in this white matter tract have been reported in patients diagnosed with chronic schizophrenia. However, it is not known whether changes in the AC are present at earlier stages of the disease. Diffusion Magnetic Resonance Images (dMRI) were acquired from 17 First Episode Schizophrenia Patients (FESZ) and 20 healthy controls. The AC was reconstructed using a streamline tractography approach. DMRI measures, including Fractional Anisotropy (FA), Trace, Axial Diffusivity (AD) and Radial Diffusivity (RD) were computed in order to assess microstructural changes in the AC. FA was reduced, while trace and RD showed increases in FESZ. AD did not show differences between groups. The observed changes in these dMRI measures, namely reductions in FA and increases in trace and RD, without changes in AD, likely point to myelin abnormalities of this white matter tract, and provide evidence of white matter pathology extant in the early phases of schizophrenia.
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在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
4.5
作者：
Kikinis Z;Asami T;Bouix S;Finn CT;Ballinger T;Tworog-Dube E;Kucherlapati R;Kikinis R;Shenton ME;Kubicki M
通讯作者：
Kubicki M
DOI：
10.1073/pnas.89.15.7199
发表时间：
1992-08-01
影响因子：
11.1
作者：
ALLEN, LS;GORSKI, RA
通讯作者：
GORSKI, RA
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
7.6
作者：
Holleran, Laurena;Ahmed, Mohamed;Cannon, Dara M.
通讯作者：
Cannon, Dara M.