Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis.
Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis.
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DOI：
10.1007/s00125-012-2491-7
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发表时间：
2012-05
期刊：
影响因子：
8.2
通讯作者：
Gotthardt, M.
中科院分区：
文献类型：
--
作者：
Andralojc, K.;Srinivas, M.;Brom, M.;Joosten, L.;de Vries, I. J. M.;Eizirik, D. L.;Boerman, O. C.;Meda, P.;Gotthardt, M.
十多年来，研究人员一直在努力开发非侵入性成像技术，用于活体胰腺细胞的测量。然而，尽管进行了大量的研究，目前只有一种用于正电子发射断层扫描（PET）成像的示踪剂处于临床评估阶段。对于许多糖尿病学家来说，为什么成像界努力开发一种有效的非侵入性β细胞成像（BCI）方法，这可能对研究和临床目的都有用，这一点可能仍然不清楚。在这里，我们简要概述了在原生和移植胰岛实现这种脑接口的过程中遇到的障碍和挑战。我们讨论了胰岛解剖和细胞生物学特征所带来的主要困难，以及主要成像方式的化学和物理限制，特别关注PET， SPECT和MRI。最后，我们根据最近几个显著的结果，指出了该领域未来研究的新途径。
For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evaluation. To many diabetologists it may remain unclear why the imaging world struggles to develop an effective method for non-invasive beta cell imaging (BCI), which could be useful for both research and clinical purposes. Here, we provide a concise overview of the obstacles and challenges encountered on the way to such BCI, in both native and transplanted islets. We discuss the major difficulties posed by the anatomical and cell biological features of pancreatic islets, as well as the chemical and physical limits of the main imaging modalities, with special focus on PET, SPECT and MRI. We conclude by indicating new avenues for future research in the field, based on several remarkable recent results.
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DOI：
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发表时间：
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影响因子：
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作者：
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