Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.
Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.
复制标题
花旗松素对体内外破骨细胞生成的影响
DOI：
10.3389/fphar.2018.01286
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发表时间：
2018
影响因子：
5.6
通讯作者：
Xiao J
中科院分区：
文献类型：
--
作者：
Cai C;Liu C;Zhao L;Liu H;Li W;Guan H;Zhao L;Xiao J
骨质疏松症是一种非常普遍的疾病，是一个主要的公共卫生问题，被认为与慢性低度全身炎症和氧化损伤有关。Taxifolin是一种天然的类黄酮，具有抗氧化、抗炎等多种药理活性。由于黄酮类化合物已被证实具有抗骨质疏松和促进骨骼健康的作用，本研究的目的是研究taxifolin对破骨细胞形成和功能的影响。在这项研究中，我们通过体外和体内研究检测了taxifolin对破骨细胞的影响。Taxifolin抑制核因子-κB、C-Fos和丝裂原活化蛋白激酶的活化，并降低破骨细胞特异性基因的表达，包括Trap、Mmp-9、Cathepsin K、C-Fos、Nfatc1和Rank。紫杉醇还能阻止RANKL刺激后活性氧（ROS）的产生。此外，在体内，taxifolin通过抑制破骨细胞活性和降低血清肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6和核因子-κB配体受体激活物（RANKL）水平，减轻卵巢切除所致的骨质流失。我们的研究结果表明，taxifolin通过调节几种RANKL信号通路来抑制破骨细胞的发生。因此，taxifolin可能被认为是治疗破骨细胞相关疾病的潜在替代治疗剂。
Osteoporosis is a highly prevalent disease which has been a major public health problem and considered to be associated with chronic low-grade systemic inflammation and oxidative damage. Taxifolin is a natural flavonoid and possesses many pharmacological activities including antioxidant and anti-inflammatory. Because flavonoids have been confirmed to fight osteoporosis and promote bone health, the aim of this study was to investigate the effects of taxifolin on the formation and function of osteoclast. In this study, we examined the effects of taxifolin on osteoclast using both in vitro and in vivo studies. Taxifolin suppressed the activation of nuclear factor-κB, C-Fos and mitogen-activated protein kinase, and also decreased osteoclast-specific genes expression, including Trap, Mmp-9, Cathepsin K, C-Fos, Nfatc1, and Rank. Taxifolin also prevented reactive oxygen species (ROS) production following RANKL stimulation. In addition, taxifolin alleviated ovariectomized-induced bone loss by repressing osteoclast activity and decreasing serum levels of tumor necrosis factor-α, interleukin-1β, interleukin-6 and receptor activator of nuclear factor-κB ligand (RANKL) in vivo. Our results indicated that taxifolin inhibits osteoclastogenesis via regulation of modulation of several RANKL signaling pathways. Therefore, taxifolin may be considered as a potential alternative therapeutic agent for treating osteoclast-related diseases.
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影响因子：
7.4
作者：
Winkel-Shirley, B
通讯作者：
Winkel-Shirley, B
影响因子：
5.8
作者：
Satue, Maria;del Mar Arriero, Maria;Maria Ramis, Joana
通讯作者：
Maria Ramis, Joana
DOI：
10.4049/jimmunol.1001591
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lee B;Kim TH;Jun JB;Yoo DH;Woo JH;Choi SJ;Lee YH;Song GG;Sohn J;Park-Min KH;Ivashkiv LB;Ji JD
通讯作者：
Ji JD
环氧类二十烷酸抑制破骨细胞生成并防止卵巢切除术引起的骨质流失。
影响因子：
4.8
作者：
Guan, Hanfeng;Zhao, Libo;Xiao, Jun
通讯作者：
Xiao, Jun
影响因子：
2.7
作者：
Galochkina, Anastasia V.;Anikin, Vadim B.;Zarubaev, Vladimir V.
通讯作者：
Zarubaev, Vladimir V.