Age-related neural changes in autobiographical remembering and imagining.
Age-related neural changes in autobiographical remembering and imagining.
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DOI：
10.1016/j.neuropsychologia.2011.09.021
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发表时间：
2011-11
期刊：
影响因子：
2.6
通讯作者：
Schacter DL
中科院分区：
文献类型：
--
作者：
Addis DR;Roberts RP;Schacter DL
许多神经影像学研究表明，在年轻人中，回忆过去和想象未来是一个共同的核心网络。虽然已经观察到老年人在这些任务中参与类似的网络，但尚不清楚他们是否以与年轻人类似的方式激活这个网络。年轻和年长的参与者完成了两个自传体任务（想象未来的事件和回忆过去的事件），除了语义视觉空间控制任务。时空偏最小二乘分析研究了整个大脑的活动模式，在建设和阐述自传体事件。这些分析表明，两个年龄组在自传体任务中激活了类似的网络。然而，这个网络的激活出现了一些与年龄相关的关键差异。在自传体事件的构建过程中，老年人在支持情节细节的区域（如内侧颞叶和楔前叶）显示出相对于年轻人较少的激活。在试验后期，老年人表现出内侧和外侧颞区网络的差异招募，支持自传体事件的阐述，并可能反映了老年人描述他们的过去和未来时概念信息的作用增加。
Numerous neuroimaging studies have revealed that in young adults, remembering the past and imagining the future engage a common core network. Although it has been observed that older adults engage a similar network during these tasks, it is unclear whether or not they activate this network in a similar manner to young adults. Young and older participants completed two autobiographical tasks (imagining future events and recalling past events) in addition to a semantic-visuospatial control task. Spatiotemporal Partial Least Squares analyses examined whole brain patterns of activity across both the construction and elaboration of autobiographical events. These analyses revealed that that both age groups activated a similar network during the autobiographical tasks. However, some key age-related differences in the activation of this network emerged. During the construction of autobiographical events, older adults showed less activation relative to younger adults, in regions supporting episodic detail such as the medial temporal lobes and the precuneus. Later in the trial, older adults showed differential recruitment of a network of medial and lateral temporal regions supporting the elaboration of autobiographical events, and possibly reflecting an increased role of conceptual information when older adults describe their pasts and their futures.
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DOI：
10.1523/jneurosci.4549-07.2007
发表时间：
2007-12-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hassabis D;Kumaran D;Maguire EA
通讯作者：
Maguire EA
影响因子：
3.7
作者：
Addis, Donna Rose;Musicaro, Regina;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
影响因子：
2.6
作者：
Addis, Donna Rose;Wong, Alana T.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR
影响因子：
3.5
作者：
Addis, Donna Rose;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.