Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis.
Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis.
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DOI：
10.1016/j.survophthal.2009.03.004
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发表时间：
2009-11
影响因子：
5.1
通讯作者：
Tseng, Scheffer C. G.
中科院分区：
文献类型：
--
作者：
Shay, Elizabeth;Kheirkhah, Ahmad;Liang, Lingyi;Sheha, Hossam;Gregory, Darren G.;Tseng, Scheffer C. G.
关键词：
Stevens-Johnson综合征及其更严重的变体中毒性表皮坏死松解症的总体发病率相对较低;然而，这种疾病的发病率和死亡率较高。大多数患者在急性期发生眼部炎症和溃疡。由于这些眼部病变的隐蔽性和对危及生命的问题的集中努力，目前的急性管理还没有制定出一个策略，以防止致盲瘢痕并发症。本文综述了最近的文献资料，显示视力威胁角膜并发症可以逐步发展的瘢痕病理的眼睑边缘，睑板，穹窿在慢性阶段。它说明了如何可以预防这种病理与早期干预的冷冻保存羊膜移植，以抑制炎症和促进上皮愈合的急性阶段。通过这种干预，也可以避免严重的干眼问题和眼恐惧症。这种新的治疗策略可以避免这种罕见但毁灭性疾病的灾难性眼科后遗症。
Stevens-Johnson syndrome and its more severe variant, toxic epidermal necrolysis, have relatively low overall incidence; however, this disease presents with high morbidity and mortality. The majority of patients develop ocular inflammation and ulceration at the acute stage. Due to the hidden nature of these ocular lesions and the concentration of effort toward life-threatening issues, current acute management has not devised a strategy to preclude blinding cicatricial complications. This review summarizes recent literature data, showing how sight-threatening corneal complications can progressively develop from cicatricial pathologies of lid margin, tarsus, and fornix at the chronic stage. It illustrates how such pathologies can be prevented with the early intervention of cryopreserved amniotic membrane transplantation to suppress inflammation and promote epithelial healing at the acute stage. Significant dry eye problems and photophobia can also be avoided with this intervention. This new therapeutic strategy can avert the catastrophic ophthalmic sequelae of this rare but devastating disease.
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