Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review.

Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review.
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DOI:
10.1111/obr.12173
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发表时间:
2014-07
期刊:
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子:
--
通讯作者:
Christensen R
Christensen R
中科院分区:
其他
文献类型:
--
作者:
Bliddal H;Leeds AR;Christensen R

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肥胖被广泛认为是骨关节炎发病和进展的危险因素,并对结局产生负面影响。减轻至少10&体重,加上运动,被认为是肥胖骨关节炎患者管理的基石,可以显著改善症状,缓解疼痛,身体功能和健康相关的生活质量。然而,围绕优化管理仍存在问题。鉴于骨关节炎给健康、社会和经济带来的巨大负担,特别是在肥胖患者中,我们必须提高对骨关节炎和肥胖的认识,并将其应用于改善护理和结局。本文概述了什么是已经知道的骨关节炎和肥胖,讨论了目前的关键挑战和正在进行的假设所产生的研究在这些领域,最后,假设什么样的未来可能持有的新视野方面的肥胖患者骨关节炎。
Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10& of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.
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