Poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment.
Poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment.
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DOI：
10.1371/journal.pone.0043647
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Bennett DA
中科院分区：
文献类型：
--
作者：
Boyle PA;Yu L;Wilson RS;Gamble K;Buchman AS;Bennett DA
决策是一生中健康和幸福的重要决定因素，但在衰老过程中尤为关键，因为许多有影响力的决定都是在认知功能衰退的时候做出的。越来越多的证据表明，老年人，甚至那些没有痴呆症的老年人，经常做出糟糕的决定，并且有选择地容易受到骗局的伤害。然而，到目前为止，与老年不良决策相关的因素尚不清楚。这项研究的目的是验证一个假设，即在没有阿尔茨海默病或轻度认知障碍的老年人中，糟糕的决策是认知能力下降的结果。参与者是420名来自记忆与衰老项目的非痴呆患者，这是一项芝加哥大都会地区衰老的纵向临床病理队列研究。所有人都接受了反复的认知评估，随后完成了决策和对骗局的敏感性评估。决策是用12个项目来衡量的，这些项目来自先前建立的基于绩效的衡量标准和对欺诈的易感性的自我报告衡量标准。认知功能数据是在决策评估前平均5.5年收集的。采用回归分析检验先前的认知衰退率是否预测了决策水平和对骗局的易感性；分析控制了年龄、性别、教育程度和初始认知水平。在420名没有痴呆的人中，认知能力下降更快预示着更差的决策能力和对骗局的易感性增加（p <0.001）。此外，在仅限于没有任何认知障碍（即没有痴呆甚至轻度认知障碍）的人的分析中，认知衰退、决策和欺诈之间的关系仍然存在。在没有阿尔茨海默病或轻度认知障碍的老年人中，糟糕的决策是认知能力下降的结果，这些老年人被广泛认为是“认知健康的”。这些发现表明，即使是非常细微的与年龄相关的认知变化，也会对判断产生不利影响。
Decision making is an important determinant of health and well-being across the lifespan but is critical in aging, when many influential decisions are made just as cognitive function declines. Increasing evidence suggests that older adults, even those without dementia, often make poor decisions and are selectively vulnerable to scams. To date, however, the factors associated with poor decision making in old age are unknown. The objective of this study was to test the hypothesis that poor decision making is a consequence of cognitive decline among older persons without Alzheimer’s disease or mild cognitive impairment. Participants were 420 non-demented persons from the Memory and Aging Project, a longitudinal, clinical-pathologic cohort study of aging in the Chicago metropolitan area. All underwent repeated cognitive evaluations and subsequently completed assessments of decision making and susceptibility to scams. Decision making was measured using 12 items from a previously established performance-based measure and a self-report measure of susceptibility to scams. Cognitive function data were collected over an average of 5.5 years prior to the decision making assessment. Regression analyses were used to examine whether the prior rate of cognitive decline predicted the level of decision making and susceptibility to scams; analyses controlled for age, sex, education, and starting level of cognition. Among 420 persons without dementia, more rapid cognitive decline predicted poorer decision making and increased susceptibility to scams (p’s<0.001). Further, the relations between cognitive decline, decision making and scams persisted in analyses restricted to persons without any cognitive impairment (i.e., no dementia or even mild cognitive impairment). Poor decision making is a consequence of cognitive decline among older persons without Alzheimer’s disease or mild cognitive impairment, those widely considered “cognitively healthy.” These findings suggest that even very subtle age-related changes in cognition have detrimental effects on judgment.
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影响因子：
9.9
作者：
Griffith, HR;Dymek, MP;Marson, DC
通讯作者：
Marson, DC
影响因子：
9.7
作者：
Heiss, Florian;McFadden, Daniel;Winter, Joachim
通讯作者：
Winter, Joachim
影响因子：
3.4
作者：
Van Wielingen, LE;Tuokko, HA;Hultsch, DF
通讯作者：
Hultsch, DF
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
DOI：
10.1093/geronb/gbq067
发表时间：
2011-01-01
影响因子：
6.2
作者：
Zamarian, Laura;Weiss, Elisabeth M.;Delazer, Margarete
通讯作者：
Delazer, Margarete