Stochastic Food Deprivation has no Effect on Cellular Immunity in the Striped Field Mouse (Apodemus agrarius)
Stochastic Food Deprivation has no Effect on Cellular Immunity in the Striped Field Mouse (Apodemus agrarius)
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随机食物剥夺对条纹田鼠（黑线姬鼠）的细胞免疫没有影响
DOI：
10.5539/ijb.v8n2p58
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Guo Qi
中科院分区：
文献类型：
--
作者：
徐德立;Bi Shi-Jia;Hu Xiao-Kai;Zhang Kai-Yue;Lü Ying-Jie;Li Dan;Wang Liu-Hong;Yao Cong-Min;Wang Shan-Shan;Guo Qi
免疫系统保护动物免受病原体的攻击，这对它们的生存和健康至关重要。由于食物资源的季节性波动，温带地区的小型哺乳动物经常面临不可预测的食物短缺。我们之前的研究表明，随机食物剥夺（FD）增加了昆明小鼠T细胞介导的免疫。在本研究中，我们验证了随机食物剥夺也会增加条纹田鼠T细胞介导的免疫的假设。雌性条纹田鼠9只，随机分为Fed组（n = 5）和FD组（n = 4）， FD组采用随机FD方案。与我们的预期相反，与喂食对照相比，随机食物剥夺对条纹田鼠T细胞介导免疫的植物血凝素（PHA）反应没有显著影响。此外，体重、体脂质量、湿胸腺和脾脏质量、白细胞和血糖水平在两组间无显著差异。综上所述，条纹田鼠在面对不可预测的食物短缺时可以保持稳定的细胞免疫。
Immune system protects animals from the attack of pathogens, which is crucial to their survival and fitness. Small mammals in the temperate area are confronted with unpredictable food shortage frequently due to the fluctuation of food resources seasonally. Our previous research has shown that stochastic food deprivation (FD) increases T cell-mediated immunity in Kunming mice. In the present study, we tested the hypothesis that stochastic food deprivation would also increase T cell-mediated immunity in the striped field mouse. Nine female striped field mouse were randomly divided into the Fed (n = 5) and FD (n = 4) groups, in which the latter were subjected to stochastic FD regime. Contrary to our expectation, stochastic food deprivation had no significant effect on phytohaemagglutinin (PHA) response indicative of T cell-mediated immunity in striped field mouse compared with the fed controls. Moreover, body mass, body fat mass, wet thymus and spleen mass, white blood cells and blood glucose levels did not differ between the Fed and FD groups. Taken together, the striped field mouse could maintain stable cellular immunity in face of unpredictable food shortage.
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影响因子：
3.8
作者：
C. Nohr;J. Tchervenkov;J. Meakins;N. Christou
通讯作者：
C. Nohr;J. Tchervenkov;J. Meakins;N. Christou
影响因子：
6.9
作者：
Ahima, Rexford S.
通讯作者：
Ahima, Rexford S.
DOI：
10.1016/j.cbpa.2006.08.045
发表时间：
2006-12-01
影响因子：
2.3
作者：
de Bellocq, Joelle Gouy;Krasnov, Boris R.;Pinshow, Berry
通讯作者：
Pinshow, Berry
影响因子：
3.1
作者：
E. Wing;J. Young
通讯作者：
E. Wing;J. Young
DOI：
10.1016/0002-9343(83)91172-5
发表时间：
1983-07
期刊：
The American journal of medicine
影响因子：
--
作者：
E. Wing;R. Stanko;A. Winkelstein;S. Adibi
通讯作者：
E. Wing;R. Stanko;A. Winkelstein;S. Adibi