A Risk Score to Detect Subclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease.
A Risk Score to Detect Subclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease.
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DOI：
10.1002/art.42162
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发表时间：
2022-11
影响因子：
13.3
通讯作者：
Dieude, Philippe
中科院分区：
文献类型：
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作者：
Juge, Pierre-Antoine;Granger, Benjamin;Debray, Marie-Pierre;Ebstein, Esther;Louis-Sidney, Fabienne;Kedra, Joanna;Doyle, Tracy J.;Borie, Raphael;Constantin, Arnaud;Combe, Bernard;Flipo, Rene-Marc;Mariette, Xavier;Vittecoq, Olivier;Saraux, Alain;Carvajal-Alegria, Guillermo;Sibilia, Jean;Berenbaum, Francis;Kannengiesser, Caroline;Boileau, Catherine;Sparks, Jeffrey A.;Crestani, Bruno;Fautrel, Bruno;Dieude, Philippe
类风湿性关节炎相关间质性肺病（RA‐ILD）高风险患者将受益于在呼吸道症状发作前进行识别;这可以通过使用胸部高分辨率计算机断层扫描（HRCT）筛选患者来完成。我们的目的是为亚临床RA‐ILD患者制定并验证风险评分。我们的研究包括来自2个前瞻性RA队列（分别为ESPOIR和TRANSLATE 2）的发现人群和复制人群，这些人群均接受了胸部HRCT扫描，无肺部症状。对所有患者进行MUC 5 B rs35705950基因分型。在多元logistic回归后，在发现人群中开发了基于亚临床RA‐ILD独立风险因素的风险评分，并在复制人群中进行了验证。发现人群包括163例RA患者，复制人群包括89例RA患者。亚临床RA‐ILD的患病率分别为19.0%和16.9%。在发现人群中，亚临床RA‐ILD的独立风险因素是MUC 5 B rs35705950 T等位基因的存在（比值比[OR] 3.74 [95%置信区间（95% CI）1.37，10.39]），男性（OR 3.93 [95% CI 1.40，11.39]），RA发作时年龄较大（每年，OR 1.10 [95%CI 1.04，1.16]），并使用红细胞沉降率增加28个关节的平均疾病活动评分（每个单位，OR 2.03 [95% CI 1.24，3.42]）。我们开发并验证了一个衍生的风险评分，发现人群的受试者操作特征曲线下面积为0.82（95%CI 0.70-0.94），复制人群为0.78（95%CI 0.65-0.92）。从模型中排除MUC 5 B rs35705950提供了较低的拟合优度（似然比检验，P = 0.01）。我们开发并验证了一种风险评分，可以帮助识别亚临床RA‐ILD高风险患者。我们的研究结果支持MUC 5 B rs35705950对亚临床RA‐ILD风险的重要贡献。
Patients at high risk of rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) would benefit from being identified before the onset of respiratory symptoms; this can be done by screening patients with the use of chest high‐resolution computed tomography (HRCT). Our objective was to develop and validate a risk score for patients who have subclinical RA‐ILD. Our study included a discovery population and a replication population from 2 prospective RA cohorts (ESPOIR and TRANSLATE2, respectively) without pulmonary symptoms who had received chest HRCT scans. All patients were genotyped for MUC5B rs35705950. After multiple logistic regression, a risk score based on independent risk factors for subclinical RA‐ILD was developed in the discovery population and tested for validation in the replication population. The discovery population included 163 patients with RA, and the replication population included 89 patients with RA. The prevalence of subclinical RA‐ILD was 19.0% and 16.9%, respectively. In the discovery population, independent risk factors for subclinical RA‐ILD were presence of the MUC5B rs35705950 T allele (odds ratio [OR] 3.74 [95% confidence interval (95% CI) 1.37, 10.39]), male sex (OR 3.93 [95% CI 1.40, 11.39]), older age at RA onset (for each year, OR 1.10 [95% CI 1.04, 1.16]), and increased mean Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (for each unit, OR 2.03 [95% CI 1.24, 3.42]). We developed and validated a derived risk score with receiver operating characteristic areas under the curve of 0.82 (95% CI 0.70–0.94) for the discovery population and 0.78 (95% CI 0.65–0.92) for the replication population. Excluding MUC5B rs35705950 from the model provided a lower goodness of fit (likelihood ratio test, P = 0.01). We developed and validated a risk score that could help identify patients at high risk of subclinical RA‐ILD. Our findings support an important contribution of MUC5B rs35705950 to subclinical RA‐ILD risk.
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影响因子：
--
作者：
Chen J;Shi Y;Wang X;Huang H;Ascherman D
通讯作者：
Ascherman D
影响因子：
3.7
作者：
Hyldgaard, Charlotte;Ellingsen, Torkell;Bendstrup, Elisabeth
通讯作者：
Bendstrup, Elisabeth
DOI：
10.3899/jrheum.200863
发表时间：
2021-05
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Kronzer VL;Huang W;Dellaripa PF;Huang S;Feathers V;Lu B;Iannaccone CK;Gill RR;Hatabu H;Nishino M;Crowson CS;Davis JM 3rd;Weinblatt ME;Shadick NA;Doyle TJ;Sparks JA
通讯作者：
Sparks JA
DOI：
10.1056/nejmoa1801562
发表时间：
2018-12-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Juge PA;Lee JS;Ebstein E;Furukawa H;Dobrinskikh E;Gazal S;Kannengiesser C;Ottaviani S;Oka S;Tohma S;Tsuchiya N;Rojas-Serrano J;González-Pérez MI;Mejía M;Buendía-Roldán I;Falfán-Valencia R;Ambrocio-Ortiz E;Manali E;Papiris SA;Karageorgas T;Boumpas D;Antoniou K;van Moorsel CHM;van der Vis J;de Man YA;Grutters JC;Wang Y;Borie R;Wemeau-Stervinou L;Wallaert B;Flipo RM;Nunes H;Valeyre D;Saidenberg-Kermanac'h N;Boissier MC;Marchand-Adam S;Frazier A;Richette P;Allanore Y;Sibilia J;Dromer C;Richez C;Schaeverbeke T;Lioté H;Thabut G;Nathan N;Amselem S;Soubrier M;Cottin V;Clément A;Deane K;Walts AD;Fingerlin T;Fischer A;Ryu JH;Matteson EL;Niewold TB;Assayag D;Gross A;Wolters P;Schwarz MI;Holers M;Solomon JJ;Doyle T;Rosas IO;Blauwendraat C;Nalls MA;Debray MP;Boileau C;Crestani B;Schwartz DA;Dieudé P
通讯作者：
Dieudé P
DOI：
10.1056/nejmoa1216076
发表时间：
2013-06-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hunninghake GM;Hatabu H;Okajima Y;Gao W;Dupuis J;Latourelle JC;Nishino M;Araki T;Zazueta OE;Kurugol S;Ross JC;San José Estépar R;Murphy E;Steele MP;Loyd JE;Schwarz MI;Fingerlin TE;Rosas IO;Washko GR;O'Connor GT;Schwartz DA
通讯作者：
Schwartz DA