Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy.
Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy.
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局部应用水凝胶脂质体进行系统靶向肿瘤光热治疗
DOI：
10.1080/10717544.2021.1974607
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发表时间：
2021-12
期刊：
影响因子：
6
通讯作者：
Wang K
中科院分区：
文献类型：
--
作者：
Chen G;Ullah A;Xu G;Xu Z;Wang F;Liu T;Su Y;Zhang T;Wang K
用于局部或全身治疗的经皮药物递送提供了具有高患者依从性的潜在抗癌模式。然而，由于生理屏障限制了所需的治疗效果，因此药物穿过皮肤的递送效率具有高度挑战性。本研究制备了肿瘤靶向光敏剂IR 780的脂质体水凝胶（IR 780/lipo/gels），用于肿瘤光热治疗（PTT）。该制剂有效地将IR 780递送至皮下肿瘤和深部转移部位，而水凝胶被施加在覆盖肿瘤的皮肤上或远处正常皮肤的区域上。在激光照射后评价局部施用的IR 780/脂质体/凝胶的光热抗肿瘤活性。我们观察到肿瘤生长速率的显著抑制，而没有与局部施用水凝胶相关的任何毒性。总的来说，IR 780/脂质体/凝胶的局部给药代表了靶向肿瘤PTT的一种新的非侵入性和安全的策略。
Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied on the skin overlying the tumor or on an area of distant normal skin. The photothermal antitumor activity of topically administered IR780/lipo/gels was evaluated following laser irradiation. We observed significant inhibition of the rate of the tumor growth without any toxicity associated with the topical administration of hydrogels. Collectively, the topical administration of IR780/lipo/gels represents a new noninvasive and safe strategy for targeted tumor PTT.
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