Pathway as a pharmacological target for herbal medicines: an investigation from reduning injection.
Pathway as a pharmacological target for herbal medicines: an investigation from reduning injection.
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热毒宁注射液作为中药药理靶点的通路研究
DOI：
10.1371/journal.pone.0123109
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Liu J;Sun K;Zheng C;Chen X;Zhang W;Wang Z;Shar PA;Xiao W;Wang Y
中医药作为一种丰富的天然药物开发资源，在补充和替代医疗体系中发挥着重要作用。中医药显示出治疗疾病的多组分、多靶点化合物的惊人复杂性，这使得使用常规方法系统地解释分子机制总是极其困难的。为了揭示中药方剂的系统机制，我们将途径整合、靶点选择、反向药物靶向和网络分析结合起来，开发了一种基于途径的策略，并以临床广泛使用的中药注射剂热毒宁注射液抗炎作用为例进行了验证。从信号通路水平系统研究了丹参主要成分的抗炎作用。更重要的是，我们的预测结果也得到了实验验证。我们的策略提供了从分子到系统水平对中药方剂药理作用的深刻理解，这可能会导致系统药理学在药物发现和开发中更成功的应用。
As a rich natural resource for drug discovery, Traditional Chinese Medicine (TCM) plays an important role in complementary and alternative medical systems. TCM shows a daunting complexity of compounds featuring multi-components and multi-targets to cure diseases, which thus always makes it extremely difficult to systematically explain the molecular mechanisms adequately using routine methods. In the present work, to reveal the systematic mechanism of herbal formulae, we developed a pathway-based strategy by combining the pathways integrating, target selection, reverse drug targeting and network analysis together, and then exemplified it by Reduning injection (RDN), a clinically widely used herbal medicine injection, in combating inflammation. The anti-inflammatory effects exerted by the major ingredients of RDN at signaling pathways level were systematically investigated. More importantly, our predicted results were also experimentally validated. Our strategy provides a deep understanding of the pharmacological functions of herbal formulae from molecular to systematic level, which may lead to more successful applications of systems pharmacology for drug discovery and development.
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药物发现和组合的系统药理学策略及其在心血管疾病中的应用
影响因子：
5.4
作者：
Li, Peng;Chen, Jianxin;Yang, Ling
通讯作者：
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DOI：
10.1016/j.bbapap.2005.08.017
发表时间：
2005-12-30
影响因子：
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作者：
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通讯作者：
Kaminska, B
影响因子：
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作者：
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Lapadat, R
影响因子：
5.7
作者：
Kim, Tae-Hoon;Yoon, Seong-Jin;Lee, Sun-Mee
通讯作者：
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DOI：
10.1093/bioinformatics/btq675
发表时间：
2011-02-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Smoot ME;Ono K;Ruscheinski J;Wang PL;Ideker T
通讯作者：
Ideker T