Impulsive choice in two different rat models of ADHD-Spontaneously hypertensive and Lphn3 knockout rats.
Impulsive choice in two different rat models of ADHD-Spontaneously hypertensive and Lphn3 knockout rats.
复制标题
DOI：
10.3389/fnins.2023.1094218
复制
发表时间：
2023
影响因子：
4.3
通讯作者：
Sable, Helen J. K.
中科院分区：
文献类型：
--
作者：
Carbajal, Monica S.;Bounmy, Asiah J. C.;Harrison, Olivia B.;Nolen, Hunter G.;Regan, Samantha L.;Williams, Michael T.;Vorhees, Charles V.;Sable, Helen J. K.
关键词：
冲动是注意力缺陷/多动障碍（ADHD）的症状，Lphn 3（Adgrl 3）基因（OMIM 616417）的变体与ADHD有关。该项目利用延迟折扣（DD）任务来检查大鼠中Lphn 3缺失对冲动选择的影响。还在自发性高血压大鼠（SHR）（另一种ADHD动物模型）中收集了“阳性对照”测量值。在实验I中，大鼠可以选择按下一个杠杆以获得3个食物颗粒的延迟奖励，或按下另一个杠杆以获得1个颗粒的立即奖励。冲动性选择被衡量为对更大的、延迟的奖励打折的倾向。我们假设，冲动的选择将是更大的SHR和Lphn 3敲除（KO）大鼠相对于他们的控制株- Wistar-Kyoto（WKY）和Lphn 3野生型（WT）大鼠，分别。结果并不完全支持这一假设，因为只有SHR（而不是Lphn 3 KO大鼠）表现出对更大奖励的选择百分比下降。因为无论选择哪一个杠杆，后续试验直到延迟期结束才开始，所以要求大鼠等待下一次试验开始，即使它们选择了立即的杠杆。实验二研究是否强化率的影响冲动的选择，使用DD任务，包括1秒的试验间隔（ITI）后立即交付的立即（1丸）或延迟（3丸）recrucer。实验二的结果发现，在Lphn 3基因敲除大鼠和野生型大鼠之间的较大奖励的百分比选择没有差异，证明强化率不影响Lphn 3基因敲除大鼠的冲动选择。总体而言，ADHD模型之间存在冲动差异，因为SHR在冲动选择方面表现出缺陷，而Lphn 3 KO大鼠则没有。
Impulsivity is a symptom of attention-deficit/hyperactivity disorder (ADHD) and variants in the Lphn3 (Adgrl3) gene (OMIM 616417) have been linked to ADHD. This project utilized a delay-discounting (DD) task to examine the impact of Lphn3 deletion in rats on impulsive choice. “Positive control” measures were also collected in spontaneously hypertensive rats (SHRs), another animal model of ADHD. For Experiment I, rats were given the option to press one lever for a delayed reward of 3 food pellets or the other lever for an immediate reward of 1 pellet. Impulsive choice was measured as the tendency to discount the larger, delayed reward. We hypothesized that impulsive choice would be greater in the SHR and Lphn3 knockout (KO) rats relative to their control strains - Wistar-Kyoto (WKY) and Lphn3 wildtype (WT) rats, respectively. The results did not completely support the hypothesis, as only the SHRs (but not the Lphn3 KO rats) demonstrated a decrease in the percent choice for the larger reward. Because subsequent trials did not begin until the end of the delay period regardless of which lever was selected, rats were required to wait for the next trial to start even if they picked the immediate lever. Experiment II examined whether the rate of reinforcement influenced impulsive choice by using a DD task that incorporated a 1 s inter-trial interval (ITI) immediately after delivery of either the immediate (1 pellet) or delayed (3 pellet) reinforcer. The results of Experiment II found no difference in the percent choice for the larger reward between Lphn3 KO and WT rats, demonstrating reinforcement rate did not influence impulsive choice in Lphn3 KO rats. Overall, there were impulsivity differences among the ADHD models, as SHRs exhibited deficits in impulsive choice, while the Lphn3 KO rats did not.
登录
查看更多内容
DOI：
10.1186/s12993-015-0084-6
发表时间：
2016-01-08
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
Gomez-Sanchez CI;Riveiro-Alvarez R;Soto-Insuga V;Rodrigo M;Tirado-Requero P;Mahillo-Fernandez I;Abad-Santos F;Carballo JJ;Dal-Ré R;Ayuso C
通讯作者：
Ayuso C
影响因子：
3.5
作者：
Hwang, In Wook;Lim, Myung Ho;Jin, Han Jun
通讯作者：
Jin, Han Jun
影响因子：
1.8
作者：
Hansen, Berit Hjelde;Oerbeck, Beate;Kristensen, Hanne
通讯作者：
Kristensen, Hanne
影响因子：
9.8
作者：
Arcos-Burgos, M;Castellanos, FX;Muenke, M
通讯作者：
Muenke, M
影响因子：
2
作者：
Acosta MT;Swanson J;Stehli A;Molina BS;MTA Team;Martinez AF;Arcos-Burgos M;Muenke M
通讯作者：
Muenke M