Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.
Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.
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DOI：
10.1038/ja.2014.122
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发表时间：
2015-03
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--
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海洋环境是独特的放线菌细菌的丰富来源，具有重要的生物和化学多样性。1，2海洋专性和海洋衍生放线菌已被证明是结构多样的次级代谢产物的来源，其中许多已被证明具有有趣的抗癌特性。3.从这一来源发现抗生素还远远不够发达，但有前途的抗生素，如蒽霉素，为进一步探索这一来源提供了重要的动力。4早些时候，我们发现海洋来源的链霉菌，菌株CNB-091产生一套至少五种结构上前所未有的缩肽，salinamides A-E，其显示出显著的抗菌和抗炎特性。5，6随后，显示盐酰胺A对来自革兰氏阳性和革兰氏阴性细菌的RNA聚合酶（RNAP）具有显著的抑制活性。7、8作为进一步探索salinamides的RNAP抑制活性的化学生物学的合作计划的一部分，我们更详细地检查了来自Streptomyces sp. CNB-091的再培养的提取物和半纯化级分，并在此报告了新的salinamide类似物salinamide F的分离，salinamide F与salinamide A一样，也具有显著的RNAP抑制和抗菌活性。
The marine environment is a rich source for unique actinomycete bacteria of significant biological and chemical diversity. 1, 2 Marineobligate and marine-derived actinomycetes have been shown to be the source of structurally diverse secondary metabolites, many of which have been shown to possess interesting anticancer properties. 3 The discovery of antibiotics from this source is far less developed, but promising antibiotics such as anthracimycin provide significant motivation to explore this source further. 4 Earlier, we showed that the marine-derived Streptomyces sp., strain CNB-091, produces a suite of at least five structurally unprecedented depsipeptides, salinamides A− E, that show significant antibacterial and anti-inflammatory properties. 5, 6 Subsequently, salinamide A was shown to possess significant inhibitory activity against RNA polymerase (RNAP) from Gram-positive and Gram-negative bacteria. 7, 8 As part of a collaborative program to further explore the chemical biology of the RNAP-inhibitory activity of the salinamides, we examined in more detail the extract and semi-purified fractions from the recultivation of Streptomyces sp. CNB-091 and report here the isolation of a new salinamide analog, salinamide F, which, like salinamide A, also possesses significant RNAP-inhibitory and antibacterial activity.
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影响因子：
5.1
作者：
Miao, SC;Anstee, MR;Brasseur, MM
通讯作者：
Brasseur, MM
影响因子：
2.9
作者：
Kuhlman, P;Duff, HL;Galant, A
通讯作者：
Galant, A
影响因子：
5.4
作者：
Srivastava, Aashish;Talaue, Meliza;Liu, Shuang;Degen, David;Ebright, Richard Y.;Sineva, Elena;Chakraborty, Anirban;Druzhinin, Sergey Y.;Chatterjee, Sujoy;Mukhopadhyay, Jayanta;Ebright, Yon W.;Zozula, Alex;Shen, Juan;Sengupta, Sonali;Niedfeldt, Rui Rong;Xin, Cai;Kaneko, Takushi;Irschik, Herbert;Jansen, Rolf;Donadio, Stefano;Connell, Nancy;Ebright, Richard H.
通讯作者：
Ebright, Richard H.
影响因子：
5.1
作者：
Kwon HC;Espindola AP;Park JS;Prieto-Davó A;Rose M;Jensen PR;Fenical W
通讯作者：
Fenical W
影响因子：
16.6
作者：
Jang, Kyoung Hwa;Nam, Sang-Jip;Fenical, William
通讯作者：
Fenical, William