Impairment of T and B cell development by treatment with a type I interferon.
Impairment of T and B cell development by treatment with a type I interferon.
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DOI：
10.1084/jem.187.1.79
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发表时间：
1998-01-05
期刊：
影响因子：
--
通讯作者：
Cooper MD
中科院分区：
文献类型：
--
作者：
Lin Q;Dong C;Cooper MD
I型干扰素α和β自然产生了细胞生长和分化的调节剂，已显示出在体外抑制IL-7诱导的B细胞前体的生长和存活率。我们用活跃的IFN-α2/α1杂交分子处理新生小鼠，以评估其在体内确定B和T细胞发育的潜力。 IFN-α2/α1-theceated小鼠中的降低，B谱系细胞降低了80％。 B谱系的骨骼骨髓中的IL-7响应细胞实际上被干扰素治疗消除了，在治疗中，骨髓中的IL-7 - 响应性细胞也被降低了80％残留的胸腺细胞表明，在分化中，抑制作用在IFN-α/β受体 - / - 小鼠中施加了数据表明，I型干扰物可以通过反对基本IL-7响应来可逆地抑制T和B细胞的早期开发。
Type I interferons α and β, naturally produced regulators of cell growth and differentiation, have been shown to inhibit IL-7–induced growth and survival of B cell precursors in vitro. After confirming an inhibitory effect on B lymphopoiesis in an ex vivo assay, we treated newborn mice with an active IFN-α2/α1 hybrid molecule to assess its potential for regulating B and T cell development in vivo. Bone marrow and splenic cellularity was greatly reduced in the IFN-α2/α1–treated mice, and B lineage cells were reduced by >80%. The bone marrow progenitor population of CD43+B220+HSA− cells was unaffected, but development of the CD19+ pro–B cells and their B lineage progeny was severely impaired. Correspondingly, IL-7–responsive cells in the bone marrow were virtually eliminated by the interferon treatment. Thymus cellularity was also reduced by >80% in the treated mice. Phenotypic analysis of the residual thymocytes indicated that the inhibitory effect was exerted during the pro–T cell stage in differentiation. In IFN-α/β receptor−/− mice, T and B cell development were unaffected by the IFN-α2/α1 treatment. The data suggest that type I interferons can reversibly inhibit early T and B cell development by opposing the essential IL-7 response.
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DOI：
10.1073/pnas.92.24.11284
发表时间：
1995-11-21
影响因子：
11.1
作者：
HWANG, SY;HERTZOG, PJ;KOLA, I
通讯作者：
KOLA, I
影响因子：
64.8
作者：
ARDAVIN, C;WU, L;SHORTMAN, K
通讯作者：
SHORTMAN, K
影响因子：
64.8
作者：
COOPER, MD;MULVANEY, D;CAZENAVE, PA
通讯作者：
CAZENAVE, PA
DOI：
10.1084/jem.181.4.1399
发表时间：
1995-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bhatia SK;Tygrett LT;Grabstein KH;Waldschmidt TJ
通讯作者：
Waldschmidt TJ
影响因子：
64.8
作者：
JOHNSTON, JA;KAWAMURA, M;O'SHEA, JJ
通讯作者：
O'SHEA, JJ