QTc interval prolongation is independently associated with severe hypoglycemic attacks in type 1 diabetes from the EURODIAB IDDM complications study.
QTc interval prolongation is independently associated with severe hypoglycemic attacks in type 1 diabetes from the EURODIAB IDDM complications study.
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DOI：
10.2337/dc11-1739
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发表时间：
2012-01
期刊：
影响因子：
16.2
通讯作者：
Bruno G
中科院分区：
文献类型：
--
作者：
Gruden G;Giunti S;Barutta F;Chaturvedi N;Witte DR;Tricarico M;Fuller JH;Cavallo Perin P;Bruno G
我们的目的是评估严重低血糖发作是否与1型糖尿病患者QTc间期异常横断面相关。该研究包括来自EURODIAB IDDM并发症研究的3248例1型糖尿病患者。严重低血糖症被定义为严重到需要另一个人的帮助。校正后的QTc间隔（QTc）为bb0.44 s，认为异常延长。19%的患者声称有一到两次发作，13.2%的患者有三次或三次以上发作。经历过三次或三次以上低血糖发作的患者QTc延长的发生率更高。Logistic回归分析显示，严重低血糖的频率与QTc延长独立相关，即使在调整糖尿病并发症（包括自主神经病变）后也是如此（优势比1.27,95% CI 1.02-1.58）。我们已经从EURODIAB IDDM并发症研究中提供了证据，证明严重低血糖发作与1型糖尿病患者QTc间隔延长独立相关。
Our aim was to assess whether severe hypoglycemic attacks were cross-sectionally associated with abnormalities of the QTc interval in type 1 diabetic patients. The study included 3,248 type 1 diabetic patients from the EURODIAB IDDM Complications Study. Severe hypoglycemia was defined as an attack serious enough to require the help of another person. A corrected QTc interval (QTc) >0.44 s was considered abnormally prolonged. Nineteen percent of patients declared one to two attacks, and 13.2% of patients had three or more attacks. Prevalence of QTc prolongation was greater in patients who experienced three or more hypoglycemic attacks. Logistic regression analysis showed that the frequency of severe hypoglycemia was independently associated with QTc prolongation, even after adjustment for diabetes complications, including autonomic neuropathy (odds ratio 1.27, 95% CI 1.02–1.58). We have provided evidence that severe hypoglycemic attacks are independently associated with a prolonged QTc interval in type 1 diabetic patients from the EURODIAB IDDM Complications Study.
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影响因子：
8.2
作者：
Tesfaye, S;Stevens, LK;Ward, JD
通讯作者：
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影响因子：
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