Caregiving stress and burden associated with cardiometabolic risk in family caregivers of individuals with cancer.
Caregiving stress and burden associated with cardiometabolic risk in family caregivers of individuals with cancer.
复制标题
DOI：
10.1080/10253890.2022.2037548
复制
发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性压力是心脏代谢性疾病的一个公认的危险因素。照顾癌症患者被认为是一种慢性应激源，但与老年人和阿尔茨海默氏症患者相反，对这一人群心脏代谢性疾病风险的研究有限。此外，很少有研究探讨家庭照顾者发生的早期生理变化，这些变化表明患病风险增加。这项横断面研究旨在检测结直肠癌患者照顾者心脏代谢风险生物标记物的水平及其相关性。照顾者完成了问卷调查，测量了暴露于压力和脆弱因素、心理痛苦和健康习惯作为潜在的相关因素。从血清中检测传统脂蛋白和非传统脂蛋白颗粒生物标志物(例如，所有脂蛋白类别的浓度和大小)。照顾者(N=83，平均年龄=49.8岁，73%为女性)显示心脏代谢生物标志物水平，表明心脏代谢疾病的风险增加。西班牙裔、已婚、受过高等教育、有工作的照顾者，据报告每天花在照看上的时间更多，经历与缺乏家庭支持和日程安排影响相关的更高照顾者负担，以及心理困扰，表明患心脏代谢性疾病的风险增加；主要由非传统脂质生物标志物--大的TRL-P、低密度脂蛋白-P、小的高密度脂蛋白-P、大的高密度脂蛋白-P、TRL-Z、低密度脂蛋白-Z和高密度脂蛋白-Z决定的。这些发现表明，传统的脂质生物标志物可能不足以检测与家庭照顾者心脏代谢性疾病风险相关的早期生理变化。此外，研究结果重申了评估照顾者负担和提供循证干预措施的重要性，以管理照顾者压力，并有可能改善照顾者的心脏代谢健康。
Chronic stress is a well-established risk factor for cardiometabolic disease. Caregiving for individuals with cancer is perceived as a chronic stressor yet research on the risk for cardiometabolic disease in this population, opposed to the elderly and those with Alzheimer’s disease, is limited. Additionally, few studies have explored the early physiological changes that occur in family caregivers suggesting an elevated risk for illness. This cross-sectional study was designed to examine levels of cardiometabolic risk biomarkers and their correlates in caregivers of patients with colorectal cancer. Caregivers completed questionnaires that measure exposures to stress and vulnerability factors, psychological distress, and health habits as potential correlates. Traditional lipid and nontraditional lipoprotein particle biomarkers (e.g. concentration and size for all lipoprotein classes) were assayed from blood serum. Caregivers (N = 83, mean age = 49.8, 73% female) displayed levels of cardiometabolic biomarkers that suggest an elevated risk for cardiometabolic disease. Caregivers who were Hispanic, married, highly educated, employed, reported more hours spent caregiving daily, experienced higher caregiver burden associated with the lack of family support and impact on schedule, and psychological distress, demonstrated an elevated risk for cardiometabolic disease; primarily determined by nontraditional lipid biomarkers – large TRL-P, LDL-P, small HDL-P, large HDL-P, TRL-Z, LDL-Z and HDL-Z. These findings suggest that traditional lipid biomarkers may not be robust enough to detect early physiological changes associated with cardiometabolic disease risk in family caregivers. Moreover, findings reiterate the importance of assessing caregiver burden and providing evidence-based interventions to manage caregiving stress with the potential to improve caregivers’ cardiometabolic health.
登录
查看更多内容
影响因子：
3.5
作者：
Kim, Youngmee;Carver, Charles S.;Shaffer, Kelly M.
通讯作者：
Shaffer, Kelly M.
影响因子：
2
作者：
GIVEN, CW;GIVEN, B;FRANKLIN, S
通讯作者：
FRANKLIN, S
影响因子：
4.3
作者：
Corwin, Elizabeth J.;Ferranti, Erin P.
通讯作者：
Ferranti, Erin P.
影响因子：
2.7
作者：
Mochari-Greenberger, Heidi;Mosca, Lori
通讯作者：
Mosca, Lori
影响因子：
5.6
作者：
Kontush A
通讯作者：
Kontush A