The association between heart rate variability and cognitive impairment in middle-aged men and women. The Whitehall II cohort study.
The association between heart rate variability and cognitive impairment in middle-aged men and women. The Whitehall II cohort study.
复制标题
DOI：
10.1159/000148257
复制
发表时间：
2008
影响因子：
5.7
通讯作者：
Shipley, Martin
中科院分区：
文献类型：
--
作者：
Britton, Annie;Singh-Manoux, Archana;Hnatkova, Katerina;Malik, Marek;Marmot, Michael G.;Shipley, Martin
为了研究一般人群中中年人心率变异性（HRV）降低与认知功能之间的关系，在英国白厅II研究的5，375名男性和女性参与者中，在平均年龄55岁和61岁时测量了两次HRV时域和频域以及认知功能。Logistic回归用于模拟HRV与认知（短期言语记忆，推理（AH 4-I），词汇，语音和语义流畅性）之间的关联。在5年的随访中，在波和纵向关联方面评估横截面关联作为认知变化。无论是在认知能力下降的横截面、前瞻性还是纵向分析中，都没有发现男性或女性之间存在一致的关联。降低心血管自主神经功能不会导致中年人群的认知功能障碍。需要进一步的研究来验证HRV测量在预测老年认知功能退化中的潜在作用。
To examine the relationship between reduced heart rate variability (HRV) and cognitive function in middle aged adults in the general population HRV, in both time and frequency domains, and cognitive function were measured twice, at mean ages 55 and 61 years, in 5,375 male and female participants of the UK Whitehall II study. Logistic regression was used to model associations between HRV and cognition (short-term verbal memory, reasoning (AH4-I), vocabulary, phonemic and semantic fluency). Cross-sectional associations were assessed at both waves and longitudinal associations as change in cognition over the 5 year follow-up. No consistent associations were found in men or women, either in cross-section, prospective or the longitudinal analysis of decline in cognition. Reduced cardiovascular autonomic function does not contribute to cognitive impairment in this middle-aged population. Further studies are needed to verify the potential role of HRV measures in predicting the degeneration of cognitive function at older ages.
登录
查看更多内容
影响因子：
168.9
作者：
Bauer, Axel;Kantelhardt, Jan W.;Schmidt, Georg
通讯作者：
Schmidt, Georg
影响因子：
5
作者：
Britton, A;Singh-Manoux, A;Marmot, M
通讯作者：
Marmot, M
影响因子：
4.2
作者：
Karlamangla, Arun S;Singer, Burton H;Seeman, Teresa E
通讯作者：
Seeman, Teresa E
DOI：
10.1111/j.1532-5415.2006.00940.x
发表时间：
2006-11-01
影响因子：
6.3
作者：
Kim, Dae Hyun;Lipsitz, Lewis A.;Chaves, Paulo H. M.
通讯作者：
Chaves, Paulo H. M.
影响因子：
2.4
作者：
Allan, LM;Kerr, SRJ;Kenny, RA
通讯作者：
Kenny, RA