How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma.
How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma.
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DOI：
10.1289/ehp.8380
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发表时间：
2006-04
影响因子：
10.4
通讯作者：
Rogers CA
中科院分区：
文献类型：
--
作者：
Gilmour MI;Jaakkola MS;London SJ;Nel AE;Rogers CA
哮喘是一种多因素气道疾病，由相对常见的遗传背景引起，与暴露于过敏原和空气中的刺激物相互作用。在过去的三十年中，西方社会中哮喘的快速增长归因于许多不同的因素，包括对疾病的认识提高，生活方式和活动模式的改变，以及环境暴露的不明确变化。人们普遍认为，哮喘患者比没有哮喘的人对空气污染物（如香烟烟雾、交通废气和光化学烟雾成分）更敏感。也有证据表明，接触过敏原和刺激物的混合物有时会促进疾病的发展阶段（诱发）。实验证据表明，柴油废气中的复杂有机分子可能通过在气道细胞中产生氧化应激而起过敏佐剂的作用。气候变化似乎也增加了花粉等空气过敏原的丰度，这可能导致过敏性疾病的发病率或严重程度增加。在这篇综述中，我们阐述了环境烟草烟雾、室外空气污染和气候变化如何作为哮喘发展的环境风险因素，并提供了这些影响如何发生的机制解释。
Asthma is a multifactorial airway disease that arises from a relatively common genetic background interphased with exposures to allergens and airborne irritants. The rapid rise in asthma over the past three decades in Western societies has been attributed to numerous diverse factors, including increased awareness of the disease, altered lifestyle and activity patterns, and ill-defined changes in environmental exposures. It is well accepted that persons with asthma are more sensitive than persons without asthma to air pollutants such as cigarette smoke, traffic emissions, and photochemical smog components. It has also been demonstrated that exposure to a mix of allergens and irritants can at times promote the development phase (induction) of the disease. Experimental evidence suggests that complex organic molecules from diesel exhaust may act as allergic adjuvants through the production of oxidative stress in airway cells. It also seems that climate change is increasing the abundance of aeroallergens such as pollen, which may result in greater incidence or severity of allergic diseases. In this review we illustrate how environmental tobacco smoke, outdoor air pollution, and climate change may act as environmental risk factors for the development of asthma and provide mechanistic explanations for how some of these effects can occur.
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影响因子：
2
作者：
Clot, Bernard
通讯作者：
Clot, Bernard
影响因子：
0.9
作者：
Frei, T
通讯作者：
Frei, T
DOI：
10.1164/ajrccm.161.5.9903006
发表时间：
2000-05-01
影响因子：
24.7
作者：
Fryer, AA;Bianco, A;Spiteri, MA
通讯作者：
Spiteri, MA
影响因子：
56.9
作者：
Fitter, AH;Fitter, RSR
通讯作者：
Fitter, RSR
影响因子：
24.3
作者：
Gehring, U;Cyrys, J;Heinrich, J
通讯作者：
Heinrich, J