Gestational exposure to particulate air pollution exacerbates the growth phenotypes induced by preconception paternal alcohol use: a multiplex model of exposure.
Gestational exposure to particulate air pollution exacerbates the growth phenotypes induced by preconception paternal alcohol use: a multiplex model of exposure.
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DOI：
10.1093/eep/dvaa011
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发表时间：
2020
影响因子：
3.8
通讯作者：
Golding MC
中科院分区：
文献类型：
--
作者：
Mustapha TA;Chang RC;Garcia-Rhodes D;Pendleton D;Johnson NM;Golding MC
现在很清楚，父母的药物使用史、毒物暴露史和社会压力都对下一代的健康和发育有重大影响。然而，表观遗传父母生活记忆与随后的妊娠暴露相互作用并累积改变后代发育轨迹的能力在毒理学中仍然是一个未探索的观点。我们实验室的研究在一个慢性、孕前父亲酒精暴露的小鼠模型中发现了雄性特异性的产后生长限制。当前研究的目的是确定父亲在怀孕前饮酒是否会改变后代对母亲在怀孕期间完全单独接触酒精的易感性。在之前的独立实验中，我们发现了妊娠期暴露于空气微粒污染中导致的发育程序改变和严重哮喘标志物增加。在这项研究中，雄性小鼠暴露于对照或酒精孕前处理，然后与幼稚的雌性交配，随后我们通过吸入将其暴露于超细颗粒物混合物中。就个体而言，孕前父亲饮酒和妊娠期暴露于颗粒空气污染中都不会影响女性后代的产后生长。然而，当这两种暴露结合在一起时，女性的体重增加减少了30%。出乎意料的是，这种暴露模式导致由于母亲同类相食而导致产仔损失的急剧增加，这阻碍了对后代健康的额外措施。这些初步研究提供了孕前生活史和宫内环境因素之间复杂的相互作用的证据，以控制出生后的生长。
It is now clear that parental histories of drug use, toxicant exposure, and social stress all have a significant influence on the health and development of the next generation. However, the ability of epigenetic parental life memories to interact with subsequent gestational exposures and cumulatively modify the developmental trajectory of the offspring remains an unexplored perspective in toxicology. Studies from our laboratory have identified male-specific postnatal growth restriction in a mouse model of chronic, preconception paternal alcohol exposure. The goal of the current study was to determine if paternal alcohol use, before conception, could modify the susceptibility of the offspring to a completely separate exposure encountered by the mother during pregnancy. In independent experiments, we previously identified altered developmental programming and increased markers of severe asthma induced by gestational exposure to particulate air pollution. In this study, male mice were exposed to either the control or alcohol preconception treatments, then mated to naive females, which we subsequently exposed to an ultrafine mixture of particulate matter via inhalation. Individually, neither preconception paternal drinking nor gestational exposures to particulate air pollution impacted the postnatal growth of female offspring. However, when both exposures were combined, females displayed a 30% reduction in weight gain. Unexpectedly, this exposure paradigm resulted in a dramatic postnatal increase in litter loss due to maternal cannibalism, which prevented additional measures of offspring health. These preliminary studies provide evidence of a complex interplay between preconception life history and intrauterine environmental factors in the control of postnatal growth.
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DOI：
10.1016/j.alcohol.2016.11.001
发表时间：
2017-05
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Rompala GR;Finegersh A;Slater M;Homanics GE
通讯作者：
Homanics GE
影响因子：
6.3
作者：
Laurent, Olivier;Bard, Denis;Segala, Claire
通讯作者：
Segala, Claire
影响因子：
3.7
作者：
Chang, Richard C.;Skiles, William M.;Golding, Michael C.
通讯作者：
Golding, Michael C.
影响因子：
3.3
作者：
Bedi, Yudhishtar;Chang, Richard C.;Golding, Michael C.
通讯作者：
Golding, Michael C.
影响因子：
120.7
作者：
Naimi, TS;Brewer, RD;Marks, JS
通讯作者：
Marks, JS