Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer's Disease.
Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer's Disease.
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DOI：
10.3390/diagnostics11050740
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发表时间：
2021-04-21
期刊：
影响因子：
--
通讯作者：
Jahng GH
中科院分区：
文献类型：
--
作者：
Choi HI;Kim K;Lee J;Chang Y;Rhee HY;Park S;Lee WI;Choe W;Ryu CW;Jahng GH
亲环蛋白 A (CypA)、血红素加氧酶-1 (HO-1) 和肌醇需求酶 1 (IRE1) 被认为与阿尔茨海默病 (AD) 相关。在这项研究中，我们研究了认知正常（CN）受试者以及遗忘性轻度认知障碍（aMCI）和 AD 受试者中灰质体积（GMV）变化与 CypA、HO-1 和 IRE1 血液水平之间的关联。 45 名老年 CN、34 名 aMCI 和 39 名 AD 受试者参加了本研究。基于体素的多元回归分析结果表明，整个人群中 CypA、HO-1 和 IRE1 的血液水平与脑磁共振成像 (MRI) 上的 GMV 相关 (p = 0.0005)。三种血清蛋白水平与整个人群中标志性 AD 区域的 GMV 相关。 CypA 值随着枕回 (r = 0.387，p < 0.0001) 和后扣带回 (r = 0.196，p = 0.034) 中 GMV 的增加而增加。 HO-1 值随着钩回 (r = 0.307，p = 0.0008)、外侧苍白球和壳核 (r = 0.287，p = 0.002) 和海马 (r = 0.197，p = 0.034) 的 GMV 增加而增加。 IRE1 值随着钩回 (r = -0.239，p = 0.010) 以及外侧苍白球和壳核 (r = -0.335，p = 0.0002) 处 GMV 的增加而降低。三种血清蛋白水平与区域GMV之间的关联表明，这些生物标志物的血液水平可能反映了大脑中AD的病理机制。
Cyclophilin A (CypA), heme oxygenase-1 (HO-1), and inositol-requiring enzyme 1 (IRE1) are believed to be associated with Alzheimer’s disease (AD). In this study, we investigated the association between gray matter volume (GMV) changes and blood levels of CypA, HO-1, and IRE1 in cognitively normal (CN) subjects and those with amnestic mild cognitive impairment (aMCI) and AD. Forty-five elderly CN, 34 aMCI, and 39 AD subjects were enrolled in this study. The results of voxel-based multiple regression analysis showed that blood levels of CypA, HO-1, and IRE1 were correlated with GMV on brain magnetic resonance imaging (MRI) in the entire population (p = 0.0005). The three serum protein levels were correlated with GMV of signature AD regions in the population as a whole. CypA values increased with increasing GMV in the occipital gyrus (r = 0.387, p < 0.0001) and posterior cingulate (r = 0.196, p = 0.034). HO-1 values increased with increasing GMV at the uncus (r = 0.307, p = 0.0008), lateral globus pallidus and putamen (r = 0.287, p = 0.002), and hippocampus (r = 0.197, p = 0.034). IRE1 values decreased with increasing GMV at the uncus (r = −0.239, p = 0.010) and lateral globus pallidus and putamen (r = −0.335, p = 0.0002). Associations between the three serum protein levels and regional GMV indicate that the blood levels of these biomarkers may reflect the pathological mechanism of AD in the brain.
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DOI：
10.1016/s1344-6223(02)00133-5
发表时间：
2003-03-01
期刊：
Legal medicine (Tokyo, Japan)
影响因子：
--
作者：
Hirose, Wataru;Ikematsu, Kazuya;Tsuda, Ryouichi
通讯作者：
Tsuda, Ryouichi
影响因子：
4
作者：
Cohen N;Breker M;Bakunts A;Pesek K;Chas A;Argemí J;Orsi A;Gal L;Chuartzman S;Wigelman Y;Jonas F;Walter P;Ernst R;Aragón T;van Anken E;Schuldiner M
通讯作者：
Schuldiner M
影响因子：
9
作者：
通讯作者：
--
影响因子：
4.5
作者：
Ahn HJ;Chin J;Park A;Lee BH;Suh MK;Seo SW;Na DL
通讯作者：
Na DL
影响因子：
6.1
作者：
Maes, Olivier C.;Kravitz, Steven;Schipper, Hyman M.
通讯作者：
Schipper, Hyman M.