Transcranial Magnetic Stimulation of Left Dorsolateral Prefrontal Cortex Induces Brain Morphological Changes in Regions Associated with a Treatment Resistant Major Depressive Episode: An Exploratory Analysis.
Transcranial Magnetic Stimulation of Left Dorsolateral Prefrontal Cortex Induces Brain Morphological Changes in Regions Associated with a Treatment Resistant Major Depressive Episode: An Exploratory Analysis.
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DOI：
10.1016/j.brs.2016.02.011
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发表时间：
2016-07
影响因子：
7.7
通讯作者：
Dubin M
中科院分区：
文献类型：
--
作者：
Lan MJ;Chhetry BT;Liston C;Mann JJ;Dubin M
重复经颅磁刺激(TMS)是FDA批准的一种抗抑郁药物治疗，但对其作用机制知之甚少。具体地说，TMS的下游效应仍有待阐明。为了通过探索性分析确定TMS治疗难治性抑郁发作后的脑结构变化，27名DSM-IV重度抑郁发作和稳定用药方案的受试者在标准TMS治疗前和治疗5周后对左侧前额叶背外侧皮质进行了3T磁共振T1结构扫描。27名健康志愿者(HV)进行了同样的脑MRI检查。基于体素的形态测量采用高维非线性扩散解剖配准(Dartel)。抑郁症患者治疗前MRI的6个灰质体积(GMV)低于高血压患者，其中4个区域的GMV在TMS治疗后增加了3.5%~11.2%。随着治疗而改变的四个脑区集中在左侧扣带回前部、左侧脑岛、左侧颞叶上回和右侧角回。TMS患者前扣带回GMV的增加与抑郁严重程度的改善相关。据我们所知，这是第一次关于经颅磁刺激治疗抑郁症期间大脑结构变化的研究。受影响的大脑区域涉及认知评估、决策和情感的主观体验。这些作用可能与TMS的抗抑郁作用有关。
Repetitive transcranial magnetic stimulation (TMS) is an FDA-approved antidepressant treatment but little is known of its mechanism of action. Specifically, downstream effects of TMS remain to be elucidated. To identify brain structural changes from TMS treatment of a treatment resistant depressive episode through an exploratory analysis 27 subjects in a DSM-IV current major depressive episode and on a stable medication regimen, had a 3T magnetic resonance T1 structural scan before and after five weeks of standard TMS treatment to the left dorsolateral prefrontal cortex. 27 healthy volunteer (HVs) subjects had the same brain MRI acquisition. Voxel-based morphometry was performed using high dimensional non-linear diffusomorphic anatomical registration (DARTEL). Six clusters of grey matter volume (GMV) that were lower in pre-treatment MRI’s of depressed subjects than in HV’s. GMV in four of these regions increased in MDD after TMS treatment by 3.5% to 11.2%. The four brain regions that changed with treatment were centered in the left anterior cingulate cortex, the left insula, the left superior temporal gyrus and the right angular gyrus. Increases in the anterior cingulate GMV with TMS correlated with improvement in depression severity. To our knowledge, this is the first study of brain structural changes during TMS treatment of depression. The affected brain areas are involved in cognitive appraisal, decision-making and subjective experience of emotion. These effects may have potential relevance for the antidepressant action of TMS.
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影响因子：
3.7
作者：
Cho SS;Strafella AP
通讯作者：
Strafella AP
DOI：
10.4088/jcp.11m07413
发表时间：
2012-04-01
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Connolly, K Ryan;Helmer, Amanda;O'Reardon, John P
通讯作者：
O'Reardon, John P
影响因子：
--
作者：
Judd, LL;Akiskal, HS;Keller, MB
通讯作者：
Keller, MB
影响因子：
7.7
作者：
Furtado, Christina P.;Hoy, Kate E.;Fitzgerald, Paul B.
通讯作者：
Fitzgerald, Paul B.
影响因子：
6.6
作者：
Han, Kyu-Man;Choi, Sunyoung;Ham, Byung-Joo
通讯作者：
Ham, Byung-Joo