A role for neonatal bacteremia in deaths due to intestinal perforation: spontaneous intestinal perforation compared with perforated necrotizing enterocolitis.
A role for neonatal bacteremia in deaths due to intestinal perforation: spontaneous intestinal perforation compared with perforated necrotizing enterocolitis.
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DOI：
10.1038/s41372-020-0691-4
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Hills NK
中科院分区：
文献类型：
--
作者：
Clyman RI;Jin C;Hills NK
探讨肠穿孔（由自发性穿孔（SIP）或坏死性小肠结肠炎（NEC）引起）与结局“肠穿孔死亡”之间的关系。采用多变量logistic回归分析比较妊娠<28周的婴儿与SIP（n=32）和穿孔NEC（n=45）的穿孔相关死亡结局。在单变量分析中，穿孔性NEC婴儿（36%）因穿孔死亡的发生率高于SIP婴儿（13%）。然而，与SIP婴儿相比，穿孔NEC婴儿更可能大于10天，并有非凝固酶阴性葡萄球菌（非CONS）微生物的菌血症/真菌血症。调整混杂因素后，与穿孔死亡率显著相关的唯一变量是穿孔发生时存在非CONS菌血症/真菌血症。死亡和穿孔性NEC之间的明显相关性可以通过穿孔性NEC婴儿中非CONS菌血症/真菌血症的发生率较高来解释。
To examine the relationship between intestinal perforations (caused by either spontaneous perforation (SIP) or necrotizing enterocolitis (NEC)) and the outcome “death due to intestinal perforation”. Multivariable logistic regression analyses were used to compare infants <28 weeks’ gestation with SIP (n=32) and perforated-NEC (n=45) for the outcome perforation-related death. In univariate analyses the incidence of death due to perforation was higher among infants with perforated-NEC (36%) than infants with SIP (13%). However, infants with perforated-NEC were more likely to be older than 10 days and have bacteremia/fungemia with non-coagulase negative staphylococci (non-CONS) organisms than infants with SIP. After adjusting for confounding the only variable that was significantly associated with mortality due to perforation was the presence of non-CONS bacteremia/fungemia at the onset of perforation. The apparent association between death and perforated-NEC could be explained by the higher incidence of non-CONS bacteremia/fungemia among infants with perforated-NEC.
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早产儿的生态失调预示着坏死性小肠结肠炎。
DOI：
10.1093/cid/ciu822
发表时间：
2015-02-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Sim K;Shaw AG;Randell P;Cox MJ;McClure ZE;Li MS;Haddad M;Langford PR;Cookson WO;Moffatt MF;Kroll JS
通讯作者：
Kroll JS
影响因子：
3.8
作者：
Normann, Erik;Fahlen, Annika;Lilja, Helene Engstrand
通讯作者：
Lilja, Helene Engstrand
影响因子：
2.9
作者：
Shah, J.;Singhal, N.;Shah, P. S.
通讯作者：
Shah, P. S.
影响因子：
2
作者：
Liebowitz, Melissa C.;Clyman, Ronald I.
通讯作者：
Clyman, Ronald I.
影响因子：
5.1
作者：
Liebowitz, Melissa;Clyman, Ronald I.
通讯作者：
Clyman, Ronald I.