Prevalence of five treatable sexually transmitted infections among women in Lower River region of The Gambia.
Prevalence of five treatable sexually transmitted infections among women in Lower River region of The Gambia.
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DOI：
10.1186/s12879-023-08399-2
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发表时间：
2023-07-13
影响因子：
3.7
通讯作者：
Clarke, Ed
中科院分区：
文献类型：
--
作者：
Butcher, Robert;Jarju, Sheikh;Obayemi, Dolapo;Bashorun, Adedapo Olufemi;Vasileva, Hristina;Bransbury-Hare, Hannah;Agboghoroma, Orighomisan;Drammeh, Lamin;Holland, Martin;Harding-Esch, Emma;Clarke, Ed
关键词：
对撒哈拉以南非洲性传播感染的流行情况描述不多。我们的目的是确定冈比亚妇女样本中5种可治疗性传播感染（沙眼衣原体、淋病奈瑟菌、阴道毛滴虫、生殖支原体、梅毒螺旋体）的患病率。在这项研究中，对420名年龄在15 - 69岁之间的冈比亚妇女的存档标本进行了检测，这些妇女参加了人乳头瘤病毒疫苗接种计划的临床试验。尿液样本进行C。trachomatis、N. gonorrhoeae、T. vagelis和M.使用市售的开放平台多重PCR试剂盒对生殖器进行PCR。从C.沙眼阳性样本并测序。检测血清样本中T。使用Chembio DPP Syphilis Screen和Confirm测试检测苍白球。总体而言，420名妇女中有41名（9.8%）至少有一项性传播感染检测呈阳性。T阳性32例（7.6%）、9例（2.1%）、1例（0.2%）、1例（0.2%）、0例（0.0%）。vagelis，C.沙眼衣原体、淋病奈瑟菌、M. genitalium和T.苍白球。ompA基因序列可从5个C.沙眼感染：4例为基因型D，1例为基因型G，1例为基因型F。性传播感染是冈比亚的地方病。应建立监测系统。在线版本包含补充材料，可通过10.1186/s12879-023-08399-2获得。
The prevalence of sexually transmitted infections (STIs) in sub-Saharan Africa is poorly described. We aimed to determine the prevalence of five treatable STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, Treponema pallidum) in a sample of Gambian women from the general population. Archived specimens from 420 women aged 15 − 69 years living in The Gambia enrolled in a clinical trial of human papilloma virus vaccine schedules were tested in this study. Urine samples were tested for C. trachomatis, N. gonorrhoeae, T. vaginalis and M. genitalium using a commercially available, open-platform multiplex PCR kit. A fragment of the ompA gene was amplified from C. trachomatis-positive samples and sequenced. Serum samples were tested for T. pallidum using the Chembio DPP Syphilis Screen and Confirm test. Overall, 41/420 (9.8%) women tested positive for at least one STI. 32 (7.6%), 9 (2.1%), 1 (0.2%), 1 (0.2%) and 0 (0.0%) tested positive for T. vaginalis, C. trachomatis, N gonorrhoeae, M. genitalium and T. pallidum, respectively. ompA gene sequence was available from five C. trachomatis infections: four were genovar D,one was genovar G and one was genovar F. STIs are endemic in The Gambia. Monitoring systems should be established. The online version contains supplementary material available at 10.1186/s12879-023-08399-2.
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影响因子：
1.8
作者：
Nabweyambo S;Kakaire O;Sowinski S;Okeng A;Ojiambo H;Kimeze J;Najjingo I;Bwanga F
通讯作者：
Bwanga F
影响因子：
14.2
作者：
Coorevits, L.;Traen, A.;Padalko, E.
通讯作者：
Padalko, E.
影响因子：
9.4
作者：
Castro, Arnold R.;Esfandiari, Javan;Ballard, Ronald C.
通讯作者：
Ballard, Ronald C.
影响因子：
3.6
作者：
Cowley G;Milne G;Teixeira da Silva E;Nakutum J;Rodrigues A;Vasileva H;Mabey D;Versteeg B;Last A
通讯作者：
Last A
影响因子：
1
作者：
Baldeh, Aru-Kumba;Isara, Alphonsus R.
通讯作者：
Isara, Alphonsus R.