Coronary artery spasm: review and update.

Coronary artery spasm: review and update.
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DOI:
10.7150/ijms.9623
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发表时间:
2014
影响因子:
3.6
通讯作者:
Hung MY
Hung MY
中科院分区:
医学4区
文献类型:
--
作者:
Hung MJ;Hu P;Hung MY

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冠状动脉痉挛(CAS)是冠状动脉的强烈血管收缩,导致血管完全或部分闭塞,在稳定型和不稳定型心绞痛、急性心肌梗死和心源性猝死等心肌缺血综合征中发挥着重要作用。通常需要冠状动脉造影和激发试验来确定明确的诊断。虽然 CAS 发生的机制仍知之甚少,但 CAS 似乎是一种多因素疾病,但与冠状动脉疾病的传统危险因素无关。 CAS 的诊断具有重要的治疗意义,因为钙拮抗剂(而不是 β 受体阻滞剂)是医学治疗的基石。预后通常被认为是良性的;然而,经常观察到心绞痛反复发作。我们回顾了文献并总结了有关 CAS 发病机制的知识现状。
Coronary artery spasm (CAS), an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion, plays an important role in myocardial ischemic syndromes including stable and unstable angina, acute myocardial infarction, and sudden cardiac death. Coronary angiography and provocative testing usually is required to establish a definitive diagnosis. While the mechanisms underlying the development of CAS are still poorly understood, CAS appears to be a multifactorial disease but is not associated with the traditional risk factors for coronary artery disease. The diagnosis of CAS has important therapeutic implications, as calcium antagonists, not β-blockers, are the cornerstone of medical treatment. The prognosis is generally considered benign; however, recurrent episodes of angina are frequently observed. We provide a review of the literature and summarize the current state of knowledge regarding the pathogenesis of CAS.
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