Global and regional estimates of orphans attributed to maternal cancer mortality in 2020.
Global and regional estimates of orphans attributed to maternal cancer mortality in 2020.
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DOI：
10.1038/s41591-022-02109-2
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发表时间：
2022-12
期刊：
影响因子：
82.9
通讯作者：
McCormack, Valerie
中科院分区：
文献类型：
--
作者：
Guida, Florence;Kidman, Rachel;Ferlay, Jacques;Schuz, Joachim;Soerjomataram, Isabelle;Kithaka, Benda;Ginsburg, Ophira;Vega, Raymond B. Mailhot;Galukande, Moses;Parham, Groesbeck;Vaccarella, Salvatore;Canfell, Karen;Ilbawi, Andre M.;Anderson, Benjamin O.;Bray, Freddie;dos-Santos-Silva, Isabel;McCormack, Valerie
尽管女性在年轻时就因癌症死亡而受到的影响尤为严重，但目前还没有对由此产生的母婴孤儿进行全球估计，这些孤儿一生都在健康和教育方面处于不利地位。我们估算了 2020 年全球 185 个国家因癌症相关死亡原因而成为母亲孤儿的儿童人数。女性癌症死亡人数——按国家、癌症类型和年龄（来自 GLOBOCAN 估计）——乘以每位妇女死亡时估计的 18 岁以下儿童数量（生育率数据来自联合国世界人口展望出生队列），从而解释了儿童死亡率和奇偶性与癌症风险的关联。全球共有 1,047,000 名此类孤儿。其中一半以上是因乳腺癌（258,000 例，25%）、宫颈癌（210,000 例，20%）和上消化道癌症（136,000 例，13%）导致的孕产妇死亡而形成的孤儿，大多数发生在亚洲（48%：印度 15%、中国 10%、亚洲其他地区 23%）和非洲（35%）。在全球范围内，每 10 万名儿童中新增 40 名因癌症产妇孤儿，随着人类发展指数的提高，这一数字呈下降趋势（范围：马拉维 121 名，马耳他 15 名）。 2020 年中期，估计有 700 万儿童因癌症而成为孤儿。加快实施世界卫生组织的宫颈癌和乳腺癌倡议不仅有可能避免数百万可预防的女性癌症死亡，而且可以避免这些死亡所带来的经常被忽视的代际后果。根据 2020 年 185 个国家的估计，亚洲和非洲因癌症导致的产妇孤儿数量最多，其中乳腺癌和宫颈癌占孕产妇癌症的近一半。
Despite women being disproportionally affected by cancer deaths at young ages, there are no global estimates of the resulting maternal orphans, who experience health and education disadvantages throughout their lives. We estimated the number of children who became maternal orphans in 2020 due to their mother dying from cancer in that year, for 185 countries worldwide and by cause of cancer-related death. Female cancer deaths—by country, cancer type and age (derived from GLOBOCAN estimates)—were multiplied by each woman’s estimated number of children under the age of 18 years at the time of her death (fertility data were derived from United Nations World Population Prospects for birth cohort), accounting for child mortality and parity-cancer risk associations. Globally, there were 1,047,000 such orphans. Over half of these were orphans due to maternal deaths from breast (258,000, 25%), cervix (210,000, 20%) and upper-gastrointestinal cancers (136,000, 13%), and most occurred in Asia (48%: India 15%, China 10%, rest of Asia 23%) and Africa (35%). Globally, there were 40 new maternal orphans due to cancer per 100,000 children, with a declining trend with a higher Human Development Index (range: 121 in Malawi to 15 in Malta). An estimated 7 million children were prevalent maternal orphans due to cancer in mid-2020. Accelerating the implementation of the World Health Organization’s cervical and breast cancer initiatives has the potential to avert not only millions of preventable female cancer deaths but also the associated, often-overlooked, intergenerational consequences of these deaths. According to 2020 estimates from 185 countries, Asia and Africa have the most maternal orphans due to cancer, with breast and cervical cancers responsible for almost half of maternal cancers.
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影响因子：
24.5
作者：
Arnold, Melina;Ferlay, Jacques;Soerjomataram, Isabelle
通讯作者：
Soerjomataram, Isabelle
影响因子：
51.1
作者：
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Bray, Freddie
影响因子：
168.9
作者：
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通讯作者：
JANSON, PO
影响因子：
4.6
作者：
Bidoli, Ettore;Virdone, Saverio;Serraino, Diego
通讯作者：
Serraino, Diego
影响因子：
25.8
作者：
Guldin, Mai-Britt;Li, Jiong;Vestergaard, Mogens
通讯作者：
Vestergaard, Mogens