The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study.
The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study.
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DOI：
10.1038/ijo.2008.274
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发表时间：
2009-02
影响因子：
4.9
通讯作者：
Gudnason, V.
中科院分区：
文献类型：
--
作者：
Eiriksdottir, G.;Smith, A. V.;Aspelund, T.;Hafsteinsdottir, S. H.;Olafsdottir, E.;Launer, L. J.;Harris, T. B.;Gudnason, V.
常见疾病通常具有由血清 CRP 水平等相关标志物反映的炎症成分。循环 CRP 水平还与脂肪组织以及特定 CRP 基因型相关。我们在确定 CRP 水平时检查了 BMI、腰围和脂肪百分比（通过生物阻抗测量的总脂肪）测量值与 CRP 基因基因型之间的相互作用。 AGES-雷克雅未克研究是一项旨在确定衰老危险因素的多学科流行病学研究，对首批 2296 名参与者（平均年龄 76±6 岁，42% 男性）的 CRP 基因中的 10 个 SNP 进行了基因分型。使用年龄和 CRP 基因型与 BMI、腰围和脂肪百分比相互作用的一般线性模型来分别评估男性和女性基因型与 CRP 水平的关联（高灵敏度方法，范围 0-10 mg/L）。我们重点关注 SNP rs1205，它代表捕获该基因对 CRP 水平最强影响的等位基因。 rs1205 G 等位基因携带者的 CRP 水平显着高于非携带者，且呈剂量依赖性。AA 纯合子男性的 CRP 随 BMI (p=0.045) 和腰围 (p=0.014) 增加而增加的斜率较低，但在女性中未达到统计学显着性。 rs1205 相互作用对于全身脂肪并不显着，表明与脂肪定位相关。 CRP 基因中的 rs1205 SNP 与循环 CRP 水平相关，其方式取决于男性的 BMI 和腰围。这表明脂肪分布对低级炎症标志物的产生有影响。
Common diseases often have an inflammatory component reflected by associated markers such as serum CRP levels. Circulating CRP levels have also been associated with adipose tissue as well as with specific CRP genotypes. We examined the interaction between measures of BMI, waist circumference and fat % (total fat measured by bioimpedance) with genotypes of the CRP gene in the determination of CRP levels. The first 2296 participants (mean age 76±6 years, 42% men) in the AGES-Reykjavik Study, a multi-disciplinary epidemiological study to determine risk factors in aging, were genotyped for 10 SNPs in the CRP gene. General linear models with age and terms for interaction of CRP genotypes with BMI, waist circumference, and percent fat were used to evaluate the association of genotypes to CRP levels (high sensitivity method, range 0- 10 mg/L) in men and women separately. We focused on the SNP rs1205 which represents the allele that captures the strongest effects of the gene on CRP levels. Carriers of the rs1205 G allele had significantly higher CRP levels than non-carriers in a dose-dependent manner, The slope of the increase in CRP with increasing BMI (p=0.045) and waist circumference (p=0.014) was lower for AA homozygous men but did not reach statistical significance in women. The rs1205 interactions were not significant for total body fat suggesting an association with fat localization. The rs1205 SNP in the CRP gene is associated with circulating CRP levels in a manner dependent on BMI and waist circumference in men. This suggests an influence of fat distribution on the production of low grade inflammatory markers.
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影响因子：
9.8
作者：
Anty, Rodolphe;Bekri, Soumeya;Gual, Philippe
通讯作者：
Gual, Philippe
影响因子：
39.3
作者：
Jonsdottir, LS;Sigfusson, N;Thorgeirsson, G
通讯作者：
Thorgeirsson, G
影响因子：
7.7
作者：
Dehghan, Abbas;Kardys, Isabella;Witteman, Jacqueline C. M.
通讯作者：
Witteman, Jacqueline C. M.
影响因子：
3.8
作者：
Lozanski, G;Jiang, SL;Kushner, I
通讯作者：
Kushner, I
DOI：
10.1196/annals.1354.036
发表时间：
2006-01-01
期刊：
UNDERSTANDING AND MODULATING AGING
影响因子：
--
作者：
Balistreri, Carmela Rita;Vasto, Sonya;Candore, Giuseppina
通讯作者：
Candore, Giuseppina