Neural and environmental factors impacting maternal behavior differences in high- versus low-novelty-seeking rats.
Neural and environmental factors impacting maternal behavior differences in high- versus low-novelty-seeking rats.
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DOI：
10.1016/j.yhbeh.2010.02.004
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发表时间：
2010-04
影响因子：
3.5
通讯作者：
Akil, Huda
中科院分区：
文献类型：
--
作者：
Clinton, Sarah M.;Bedrosian, Tracy A.;Abraham, Antony D.;Watson, Stanley J.;Akil, Huda
对表现出新奇诱导运动差异的大鼠进行选择性繁殖，发现这种特征预示着情绪行为的几种差异。繁殖高反应者（bHR）表现出夸大的新奇诱导的运动，侵略性和精神兴奋剂自我管理，相比繁殖低反应者（bLR），这是抑制和倾向于焦虑和抑郁样行为。我们的育种研究强调了bHR/bLR表型的遗传性，尽管环境因素如母亲护理也会影响这些性状的某些方面。我们之前曾报道过HR和LR母亲的行为不同，但尚不清楚她们的行为是由基因驱动还是受到幼崽的影响。本研究（a）使用交叉寄养来评估bHR/bLR母体类型是否是母体固有的和/或由幼崽调节;和（B）评估催产素和催产素受体mRNA表达以检查bHR/bLR母体差异的可能基础。虽然bHR母鼠在黑暗/活跃阶段表现出比bLR更少的母性行为，但它们在光照阶段非常关注幼崽，与bLR相比，花费更多的时间被动护理和与幼崽接触。交叉寄养只微妙地改变了bHR和bLR母鼠的行为，这表明它们独特的母性风格在很大程度上是母亲固有的。我们还发现bHR与bLR母鼠下丘脑视上核中催产素mRNA水平升高，这可能在驱动其行为差异方面发挥一定作用。总的来说，这些研究揭示了母亲和婴儿的遗传学之间的相互作用，在驱动母亲风格的差异。
Selective breeding of rats exhibiting differences in novelty-induced locomotion revealed that this trait predicts several differences in emotional behavior. Bred High Responders (bHRs) show exaggerated novelty-induced locomotion, aggression, and psychostimulant self-administration, compared to bred Low Responders (bLRs), which are inhibited and prone to anxiety- and depression-like behavior. Our breeding studies highlight the heritability of the bHR/bLR phenotypes, although environmental factors like maternal care also shape some aspects of these traits. We previously reported that HR vs. LR mothers act differently, but it was unclear whether their behaviors were genetically driven or influenced by their pups. The present study (a) used cross-fostering to evaluate whether the bHR/bLR maternal styles are inherent to mothers and/or are modulated by pups; and (b) assessed oxytocin and oxytocin receptor mRNA expression to examine possible underpinnings of bHR/bLR maternal differences. While bHR dams exhibited less maternal behavior than bLRs during the dark/active phase, they were very attentive to pups during the light phase, spending greater time passive nursing and in contact with pups compared to bLRs. Cross-fostering only subtly changed bHR and bLR dams’ behavior, suggesting that their distinct maternal styles are largely inherent to the mothers. We also found elevated oxytocin mRNA levels in the supraoptic nucleus of the hypothalamus in bHR versus bLR dams, which may play some role in driving their behavior differences. Overall these studies shed light on the interplay between the genetics of mothers and infants in driving differences in maternal style.
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影响因子：
3.3
作者：
Ballaz, S. J.;Akil, H.;Watson, S. J.
通讯作者：
Watson, S. J.
影响因子：
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作者：
Fleming, AS;Korsmit, M
通讯作者：
Korsmit, M
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作者：
BROUETTELAHLOU, I;VERNETMAURY, E;VIGOUROUX, M
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VIGOUROUX, M
影响因子：
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作者：
Flagel, Shelly B.;Robinson, Terry E.;Clark, Jeremy J.;Clinton, Sarah M.;Watson, Stanley J.;Seeman, Phillip;Phillips, Paul E. M.;Akil, Huda
通讯作者：
Akil, Huda
影响因子：
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作者：
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通讯作者：
Rinaman, L