Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells.
Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells.
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DOI：
10.1111/j.1582-4934.2011.01506.x
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发表时间：
2012-04
影响因子：
5.3
通讯作者：
Koh SD
中科院分区：
文献类型：
--
作者：
Koh BH;Roy R;Hollywood MA;Thornbury KD;McHale NG;Sergeant GP;Hatton WJ;Ward SM;Sanders KM;Koh SD
特定类别的间质细胞存在于内脏器官中，并参与多种生理功能，包括神经传递中的起搏和介质。据报道，在膀胱中存在Kit+间质细胞，并被认为是神经调质。最近，在胃肠道（GI）中描述了第二种间质细胞，其使用血小板衍生生长因子受体-α（PDGFR-α）抗体鉴定，并与肠道运动神经传递有关。本研究观察了PDGFR-α+细胞在小鼠膀胱中的分布及其与神经纤维和平滑肌细胞的关系。血小板衍生生长因子受体-α+细胞呈梭形或星状形态，通常具有多个突起，相互接触形成松散的网络。这些细胞分布在整个膀胱壁，存在于固有层以及整个逼尿肌肌层。这些细胞包围并位于平滑肌束之间，并经常与壁内神经纤维形成密切的形态学联系。这些数据描述了一类新的间质细胞，表达膀胱壁内的特异性受体，并提供了形态学证据，可能在膀胱功能的神经调节作用。
Specific classes of interstitial cells exist in visceral organs and have been implicated in several physiological functions including pacemaking and mediators in neurotransmission. In the bladder, Kit+ interstitial cells have been reported to exist and have been suggested to be neuromodulators. More recently a second interstitial cell, which is identified using antibodies against platelet-derived growth factor receptor-α (PDGFR-α) has been described in the gastrointestinal (GI) tract and has been implicated in enteric motor neurotransmission. In this study, we examined the distribution of PDGFR-α+ cells in the murine urinary bladder and the relation that these cells may have with nerve fibres and smooth muscle cells. Platelet-derived growth factor receptor-α+ cells had a spindle shape or stellate morphology and often possessed multiple processes that contacted one another forming a loose network. These cells were distributed throughout the bladder wall, being present in the lamina propria as well as throughout the muscularis of the detrusor. These cells surrounded and were located between smooth muscle bundles and often came into close morphological association with intramural nerve fibres. These data describe a new class of interstitial cells that express a specific receptor within the bladder wall and provide morphological evidence for a possible neuromodulatory role in bladder function.
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影响因子：
5.3
作者：
Kostin S
通讯作者：
Kostin S
DOI：
10.1016/s0165-1838(00)00089-8
发表时间：
2000-05-12
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
Horiguchi, K;Komuro, T
通讯作者：
Komuro, T
影响因子：
5.5
作者：
Kurahashi, Masaaki;Zheng, Haifeng;Sanders, Kenton M.
通讯作者：
Sanders, Kenton M.
影响因子：
7.3
作者：
Hashitani, H.;Hayase, M.;Suzuki, H.
通讯作者：
Suzuki, H.
DOI：
10.1007/bf01181533
发表时间：
1995-03-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
GABELLA, G
通讯作者：
GABELLA, G