Myocardial telocytes: a specific new cellular entity.
Myocardial telocytes: a specific new cellular entity.
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DOI：
10.1111/j.1582-4934.2010.01111.x
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发表时间：
2010-07
影响因子：
5.3
通讯作者：
Kostin S
中科院分区：
文献类型：
--
作者：
Kostin S
Hinescu和Popescu在2005年首次描述了心脏中存在一种新的间质细胞，即间质cajal样细胞（ICLC）。这项研究之后，关于包括人类患者在内的不同物种心肌ICLC的形态学、表型和分布的出版物呈上升趋势。最近，人们提出了新的术语“远端细胞”来描述以前称为ICLC的细胞，并提出了“远端足”来描述这些细胞的延长。这些细胞的鉴定是基于超微结构标准。此外，还可以通过亚甲基蓝生命染色、银浸渍和对CD117/c-kit、vimentin的免疫反应等几种互补方法来鉴定终足细胞/终足细胞。这一观点提出了文献中存在的关键数据，以及自己的结果，明确地提供了令人信服的证据，表明远端细胞是心肌间质中一个新的独特的细胞实体。本文讨论了心肌远端细胞的几种可能功能：(i)细胞间信号传导，（ii）心脏修复/重构，（iii）心脏更新中的干细胞护理。
The existence of a new type of interstitial cells in the heart namely, interstitial Cajal-like cells (ICLC), has been described for the first time by Hinescu and Popescu in 2005. This study was then followed by an ascending trend of publications regarding the morphology, phenotype and distribution of myocardial ICLC in diverse species including human patients. Recently the new term ‘telocytes’ has been proposed for cells formerly known as ICLC, and the term ‘telopodes’ has been proposed for the prolongations of these cells. The identification of these cells is based on ultrastructural criteria. In addition, telocyters/telyopodes can be identified by several complementary approaches including methylene blue vital staining, silver impregnation and immunoreactivity against CD117/c-kit, vimentin, etc. This point of view presents critical data existing in literature, as well as own results, which unequivocally provide compelling evidence that telocytes are a new distinct cellular entity of myocardial interstitium. Several presumable functions of the myocardial telocytes are discussed: (i) intercellular signalling, (ii) cardiac repair/remodelling and (iii) stem cell nursing in cardiac renewal.
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DOI：
10.1111/j.1582-4934.2006.tb00410.x
发表时间：
2006-04
影响因子：
5.3
作者：
Popescu LM;Gherghiceanu M;Hinescu ME;Cretoiu D;Ceafalan L;Regalia T;Popescu AC;Ardeleanu C;Mandache E
通讯作者：
Mandache E
DOI：
10.1111/j.1582-4934.2006.tb00306.x
发表时间：
2006-01
影响因子：
5.3
作者：
Hinescu ME;Gherghiceanu M;Mandache E;Ciontea SM;Popescu LM
通讯作者：
Popescu LM
影响因子：
3.2
作者：
Cretoiu, Sanda Maria;Cretoiu, D.;Popescu, L. M.
通讯作者：
Popescu, L. M.
影响因子：
5
作者：
Limana, Federica;Bertolami, Chiara;Capogrossi, Maurizio C.
通讯作者：
Capogrossi, Maurizio C.
影响因子：
5.3
作者：
Suciu L;Popescu LM;Regalia T;Ardelean A;Manole CG
通讯作者：
Manole CG