The multifunctional nature of mitochondrial contact site proteins.

The multifunctional nature of mitochondrial contact site proteins.
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DOI:
10.1016/j.ceb.2020.02.010
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发表时间:
2020-08
影响因子:
7.5
通讯作者:
Lackner LL
Lackner LL
中科院分区:
生物学2区
文献类型:
--
作者:
Harper CS;White AJ;Lackner LL

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线粒体与细胞中几乎所有其他膜都有物理接触,这些接触具有丰富的功能,这些功能是由接触部位的蛋白质执行的。在过去的十年中,人们对位于线粒体接触位点的蛋白质的身份和功能有了深入的了解。在此过程中,已经清楚的是,一种蛋白质或蛋白质复合物可以以多种方式促进接触位点的形成和功能。因此,线粒体接触位点与其多功能驻留蛋白之间复杂且常常令人惊讶的关系不断被阐明。
Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a rich variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondria contact sites has been gained. In doing so, it has become clear that one protein or protein complex can contribute to contact site formation and function in a wide variety of ways. Thus, complex and often surprising relationships between the roles of a mitochondria contact site and its multifunctional resident proteins continue to be unraveled.
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