Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease

Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease
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血管性痴呆和阿尔茨海默病临床前阶段认知缺陷的相似模式

DOI:
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发表时间:
2004
影响因子:
2.6
通讯作者:
L. Bäckman
L. Bäckman
中科院分区:
心理学3区
文献类型:
--
作者:
E. Laukka;Sari Jones;B. Small;L. Fratiglioni;L. Bäckman

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我们调查了(1)3年后将被诊断为血管性痴呆(VaD)的人是否存在认知缺陷,以及(2)这种缺陷的模式与临床前阿尔茨海默病(AD)中观察到的模式相似。VaD诊断是中风后痴呆的诊断。对15例VaD事件、43例AD事件和149名正常对照的人群样本进行了情景记忆和短期记忆、言语流畅性和视觉空间技能测试进行了比较。两个痴呆组在诊断前3年评估情景记忆的任务上均显示出临床前损害相对控制,并且这些组之间在任何认知测量上均无差异。本VaD病例中存在临床前阶段表明,在导致临床VaD的卒中发生之前,循环障碍可能会影响认知能力。这些结果扩展了以前的发现类似的模式认知缺陷的早期临床阶段的AD和VaD的临床前阶段,这些疾病。(JINS,2004,10,382-391.)
We investigated whether (1) cognitive deficits are present among persons who will be diagnosed with vascular dementia (VaD) 3 years later, and (2) the pattern of such deficits is similar to that observed in preclinical Alzheimer's disease (AD). The VaD diagnosis was a diagnosis of post-stroke dementia. Population-based samples of 15 incident VaD cases, 43 incident AD cases, and 149 normal controls were compared on tests of episodic and short-term memory, verbal fluency, and visuospatial skill. Both dementia groups showed preclinical impairment relative controls on tasks assessing episodic memory 3 years before diagnosis, and there were no differences between these groups on any cognitive measure. The existence of a preclinical phase in the present VaD cases suggests that circulatory disturbance may affect cognitive performance before the occurrence of stroke that leads to clinical VaD. These results extend previous findings of similar patterns of cognitive deficits in the early clinical phases of AD and VaD to the preclinical phases of these diseases. (JINS, 2004, 10, 382–391.)
DOI: 10.1001/jama.1995.03530230032026
发表时间: 1995-12
期刊: JAMA
影响因子: --
作者:
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通讯作者: L. Launer;K. Masaki;H. Petrovitch;D. Foley;R. Havlik
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发表时间: 2002-07-03
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