The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being.
The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being.
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DOI：
10.1186/1471-2318-10-35
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发表时间：
2010-06-09
期刊：
影响因子：
4.1
通讯作者：
Hirose N
中科院分区：
文献类型：
--
作者：
Arai Y;Iinuma T;Takayama M;Takayama M;Abe Y;Fukuda R;Ando J;Ohta K;Hanabusa H;Asakura K;Nishiwaki Y;Gondo Y;Akiyama H;Komiyama K;Gionhaku N;Hirose N
随着世界范围内高龄老年人口的迅速增加，人们对这一年龄段的疾病和残疾造成的社会和经济负担引起了相当大的关注。了解健康的多维结构及其生命轨迹是有效提供卫生保健的基本前提。因此，我们组织了一个由老年病医生、牙医、心理学家、社会学家和流行病学家组成的跨学科研究小组进行了一项纵向观察性研究。在东京最古老的全面健康调查(牙齿)研究中，从东京市基本登记处随机抽取了85岁或以上的居民作为样本。基线综合评估包括一次家庭访谈、一份自填式问卷和一次体检/牙科检查。为了进行各种各样的生物医学测量，包括颈动脉超声和详细的牙科检查，参与者被邀请到庆应大学医院的研究中心。对于那些不能访问研究中心的人，我们提供了基于家庭的检查选项，在检查中，参与者同时接受一名老年病医生和一名牙医的访问。在2875名符合条件的个人中，共招募了1152人，其中542人同时完成了上门访谈和体检/牙科检查，442人只完成了上门访谈，另外168人只完成了自我或代理管理的数据收集。完成颈动脉超声检查458例，占来访者的99.6%(n=460)。421名受试者完成了使用可变色口香糖的咀嚼评估，占门诊就诊者的91.5%。我们的结果证明了一项新的综合性研究的可行性，该研究结合了亚临床疾病的非侵入性测量和针对85岁或以上社区居住的个人的详细牙科检查。双峰招募战略对于获取年龄最大的老年人的广泛健康状况至关重要。牙齿研究的结果将有助于开发新的健康促进模式，预计将有助于改善终身健康和福祉。这项研究已在UMIN-临床试验注册中心(CTR)注册，ID：UMIN000001842。
With the rapid worldwide increase in the oldest old population, considerable concern has arisen about the social and economic burden of diseases and disability in this age group. Understanding of multidimensional structure of health and its life-course trajectory is an essential prerequisite for effective health care delivery. Therefore, we organized an interdisciplinary research team consisting of geriatricians, dentists, psychologists, sociologists, and epidemiologists to conduct a longitudinal observational study. For the Tokyo Oldest Old Survey on Total Health (TOOTH) study, a random sample of inhabitants of the city of Tokyo, aged 85 years or older, was drawn from the basic city registry. The baseline comprehensive assessment consists of an in-home interview, a self-administered questionnaire, and a medical/dental examination. To perform a wide variety of biomedical measurements, including carotid ultrasonography and a detailed dental examination, participants were invited to our study center at Keio University Hospital. For those who were not able to visit the study center, we provided the option of a home-based examination, in which participants were simultaneously visited by a geriatrician and a dentist. Of 2875 eligible individuals, a total of 1152 people were recruited, of which 542 completed both the in-home interview and the medical/dental examination, with 442 completed the in-home interview only, and another 168 completed self or proxy-administered data collection only. Carotid ultrasonography was completed in 458 subjects, which was 99.6% of the clinic visitors (n = 460). Masticatory assessment using a colour-changeable chewing gum was completed in 421 subjects, a 91.5% of the clinic visitors. Our results demonstrated the feasibility of a new comprehensive study that incorporated non-invasive measurements of subclinical diseases and a detailed dental examination aiming at community-dwelling individuals aged 85 years or older. The bimodal recruitment strategy is critically important to capture a broad range of health profiles among the oldest old. Results form the TOOTH study will help develop new models of health promotion, which are expected to contribute to an improvement in lifelong health and well-being. This study has been registered in the UMIN-Clinical Trial Registry (CTR), ID: UMIN000001842.
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DOI：
10.1073/pnas.0804931105
发表时间：
2008-09-09
影响因子：
11.1
作者：
Christensen, Kaare;McGue, Matt;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
8.3
作者：
Desvarieux, M;Demmer, RT;Sacco, RL
通讯作者：
Sacco, RL
影响因子：
9.9
作者：
Juva, K;Verkkoniemi, A;Sulkava, R
通讯作者：
Sulkava, R
影响因子：
158.5
作者：
Beckett, Nigel S.;Peters, Ruth;Bulpitt, Christopher J.
通讯作者：
Bulpitt, Christopher J.
影响因子：
4.1
作者：
Leveille SG;Kiel DP;Jones RN;Roman A;Hannan MT;Sorond FA;Kang HG;Samelson EJ;Gagnon M;Freeman M;Lipsitz LA
通讯作者：
Lipsitz LA