Predictive utility of the Framingham general cardiovascular disease risk profile for cognitive function: evidence from the Whitehall II study.
Predictive utility of the Framingham general cardiovascular disease risk profile for cognitive function: evidence from the Whitehall II study.
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DOI：
10.1093/eurheartj/ehr133
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发表时间：
2011-09
影响因子：
39.3
通讯作者：
Singh-Manoux A
中科院分区：
文献类型：
--
作者：
Kaffashian S;Dugravot A;Nabi H;Batty GD;Brunner E;Kivimäki M;Singh-Manoux A
血管危险因素与认知障碍和痴呆有关，尽管这一领域的研究大多集中在脑血管因素上。我们研究了最近发展的弗雷明汉一般心血管风险概况和认知功能与中年晚期10年下降之间的关系。研究样本由3486名男性和1341名女性组成，平均年龄55岁[标准差(SD)=6]，来自英国纵向队列研究Whitehall II研究。1997年至1999年间评估的Framingham心血管风险概况包括年龄、性别、高密度脂蛋白胆固醇、总胆固醇、收缩压、吸烟状况和糖尿病状况。认知功能测试包括推理（Alice Heim 4-I）、记忆、音素和语义流畅性以及词汇（Mill-Hill）测试，在10年内评估了三次（1997 - 1999,2002 - 2004,2007 - 2009）。在年龄调整的横断面模型中，心血管风险增加10%与男性和女性在所有认知领域的表现不佳相关（所有p值<0.001）。在调整了年龄、种族、婚姻状况和教育程度的模型中，心血管风险增加10%与男性总体10年认知能力下降有关，尤其是推理能力下降（- 0.47;95% CI: - 0.81, - 0.11）。在没有心血管疾病的中年个体中，不良的心血管风险概况与认知功能差和男性至少一个认知领域的下降有关。
Vascular risk factors are associated with cognitive impairment and dementia, although most of the research in this domain focuses on cerebrovascular factors. We examined the relationship between the recently developed Framingham general cardiovascular risk profile and cognitive function and 10-year decline in late midlife. Study sample comprised of 3486 men and 1341 women, mean age 55 years [standard deviation (SD)=6], from the Whitehall II study, a longitudinal British cohort study. The Framingham General Cardiovascular Risk profile, assessed between 1997 and 1999, included age, sex, HDL cholesterol, total cholesterol, systolic blood pressure, smoking status, and diabetes status. Measures of cognitive function consisted of tests of reasoning (Alice Heim 4-I), memory, phonemic and semantic fluency, and vocabulary (Mill-Hill), assessed three times (1997–1999, 2002–2004, 2007–2009) over 10 years. In cross-sectional age-adjusted models, 10% point increments in cardiovascular risk were associated with poor performance in all cognitive domains in both men and women (all P-values <0.001). In models adjusted for age, ethnicity, marital status, and education, 10% higher cardiovascular risk was associated with greater overall 10-year cognitive decline in men, reasoning in particular (−0.47; 95% CI: −0.81, −0.11). In middle-aged individuals free of cardiovascular disease, an adverse cardiovascular risk profile is associated with poor cognitive function, and decline in at least one cognitive domain in men.
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DOI：
10.1093/geronb/56.6.p340
发表时间：
2001-11-01
影响因子：
6.2
作者：
Brady, CB;Spiro, A;Gaziano, JM
通讯作者：
Gaziano, JM
影响因子：
--
作者：
Kivipelto, M;Ngandu, T;Nissinen, A
通讯作者：
Nissinen, A
影响因子：
105.7
作者：
Kivipelto, M;Helkala, EL;Nissien, A
通讯作者：
Nissien, A
影响因子：
7.2
作者：
Singh-Manoux, A;Marmot, M
通讯作者：
Marmot, M
DOI：
10.1093/geronb/59.2.p84
发表时间：
2004-03-01
影响因子：
6.2
作者：
Rabbitt, P;Diggle, P;McInnes, L
通讯作者：
McInnes, L