The known unknowns of the human dendritic cell network.

The known unknowns of the human dendritic cell network.
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DOI:
10.3389/fimmu.2015.00129
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发表时间:
2015
影响因子:
7.3
通讯作者:
Segura E
Segura E
中科院分区:
医学2区
文献类型:
--
作者:
Durand M;Segura E

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树突状细胞 (DC) 启动和定向免疫反应,并包含几个表现出不同表型和特性的亚群。我们对 DC 亚群生物学的大部分了解都基于小鼠研究。在过去的几年里,人类DC网络与小鼠DC网络的对齐一直是备受关注的焦点。尽管比较表型和转录组分析显示小鼠和人类 DC 亚群之间具有高度同源性,但也证明了表型和功能的显着差异。在这里,我们回顾了对人类 DC 网络理解的最新进展,并讨论了人类 DC 领域的一些剩余差距和未来挑战。
Dendritic cells (DCs) initiate and orient immune responses and comprise several subsets that display distinct phenotypes and properties. Most of our knowledge of DC subsets biology is based on mouse studies. In the past few years, the alignment of the human DC network with the mouse DC network has been the focus of much attention. Although comparative phenotypic and transcriptomic analysis have shown a high level of homology between mouse and human DC subsets, significant differences in phenotype and function have also been evidenced. Here, we review recent advances in our understanding of the human DC network and discuss some remaining gaps and future challenges of the human DC field.
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