Circulating precursors of human CD1c+ and CD141+ dendritic cells.
Circulating precursors of human CD1c+ and CD141+ dendritic cells.
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DOI：
10.1084/jem.20141441
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发表时间：
2015-03-09
期刊：
影响因子：
--
通讯作者：
Nussenzweig MC
中科院分区：
文献类型：
--
作者：
Breton G;Lee J;Zhou YJ;Schreiber JJ;Keler T;Puhr S;Anandasabapathy N;Schlesinger S;Caskey M;Liu K;Nussenzweig MC
Liu和Nussenzweig小组鉴定了健康供体循环中CD 1c+和CD 141+树突状细胞的直接前体。这些前体细胞（hpre-cDC）在脐带血、骨髓、血液和外周淋巴器官中可检测到。在小鼠和人中存在两个具有不同细胞表面标志物和功能的常规树突状细胞（cDC）亚群。cDC的两个子集是启动T细胞免疫和耐受的特化抗原呈递细胞。在小鼠中，迁移性cDC前体（pre-CDC）来源于骨髓（BM）中确定的祖细胞。少量短寿命的前CDC穿过血液并取代外周器官中的cDC，维持高度动态的cDC库的稳态。然而，尚未确定人cDC的直接前体的身份和分布。使用支持人DC发育的组织培养系统，我们鉴定了存在于人脐带血、BM、血液和外周淋巴器官中的迁移前体（hpre-CDC）。hpre-CDC不同于局限于BM的前单核细胞。与具有更大发育潜力的早期祖细胞相比，hpre-CDC仅限于产生CD 1c+和CD 141 + Clec 9a + cDC。在人类志愿者中的研究表明，hpre-CDC是响应于循环Flt 3L水平而增加的动态群体。
The Liu and Nussenzweig groups identify the immediate precursor of CD1c+ and CD141+ dendritic cells in the circulation of healthy donors. These precursor cells (hpre-cDC) were detectable in cord blood, bone marrow, blood, and peripheral lymphoid organs. Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse and human. The two subsets of cDCs are specialized antigen-presenting cells that initiate T cell immunity and tolerance. In the mouse, a migratory cDC precursor (pre-CDC) originates from defined progenitors in the bone marrow (BM). Small numbers of short-lived pre-CDCs travel through the blood and replace cDCs in the peripheral organs, maintaining homeostasis of the highly dynamic cDC pool. However, the identity and distribution of the immediate precursor to human cDCs has not been defined. Using a tissue culture system that supports the development of human DCs, we identify a migratory precursor (hpre-CDC) that exists in human cord blood, BM, blood, and peripheral lymphoid organs. hpre-CDCs differ from premonocytes that are restricted to the BM. In contrast to earlier progenitors with greater developmental potential, the hpre-CDC is restricted to producing CD1c+ and CD141+ Clec9a+ cDCs. Studies in human volunteers demonstrate that hpre-CDCs are a dynamic population that increases in response to levels of circulating Flt3L.
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影响因子：
30.5
作者：
Liu, Kang;Waskow, Claudia;Nussenzweig, Michel
通讯作者：
Nussenzweig, Michel
影响因子：
32.4
作者：
Kabashima, K;Banks, TA;Cyster, JG
通讯作者：
Cyster, JG
DOI：
10.1084/jem.20092140
发表时间：
2010-06-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jongbloed SL;Kassianos AJ;McDonald KJ;Clark GJ;Ju X;Angel CE;Chen CJ;Dunbar PR;Wadley RB;Jeet V;Vulink AJ;Hart DN;Radford KJ
通讯作者：
Radford KJ
DOI：
10.1084/jem.20092618
发表时间：
2010-06-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Poulin LF;Salio M;Griessinger E;Anjos-Afonso F;Craciun L;Chen JL;Keller AM;Joffre O;Zelenay S;Nye E;Le Moine A;Faure F;Donckier V;Sancho D;Cerundolo V;Bonnet D;Reis e Sousa C
通讯作者：
Reis e Sousa C
影响因子：
15.3
作者：
Chicha, L;Jarrossay, D;Manz, MG
通讯作者：
Manz, MG