The Cellular Composition of the Uveal Immune Environment.
The Cellular Composition of the Uveal Immune Environment.
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DOI：
10.3389/fmed.2021.721953
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发表时间：
2021
影响因子：
3.9
通讯作者：
Buckley CD
中科院分区：
文献类型：
--
作者：
Reekie IR;Sharma S;Foers A;Sherlock J;Coles MC;Dick AD;Denniston AK;Buckley CD
葡萄膜由虹膜、睫状体和脉络膜组成；这三种不同的组织在眼睛内形成一个连续的层。葡萄膜炎是指葡萄膜任何区域的炎症。尽管在解剖学上被归为一类，但虹膜、睫状体和脉络膜在功能上是不同的，炎症性疾病可能只影响其中一个部分，而不影响其他部分。组织的细胞结构指导其功能，了解健康组织免疫环境的细胞基础（叠加疾病扰动的“稳态”）对于了解这些疾病的发病机制至关重要。现代对免疫系统的理解认为，造血细胞和卵黄囊来源的白细胞虽然至关重要，但并不是唯一重要的参与者。一系列基质细胞、结缔组织细胞（如成纤维细胞和内皮细胞）也可能在几种免疫介导疾病中出现的炎症反应中发挥作用。在这篇综述中，我们总结了关于葡萄膜细胞组成的已知信息以及这些不同的细胞类型在免疫稳态中所发挥的作用。我们还讨论了一些围绕不同葡萄膜组织的常驻白细胞群组成的悬而未决的问题，我们期待着新的认识，即单细胞转录组学、多组学数据集成和高度多重成像技术等现代研究技术可能会给葡萄膜和葡萄膜炎的研究带来新的认识，就像它们已经对其他免疫介导的炎症性疾病进行研究一样。
The uveal tract consists of the iris, the ciliary body and the choroid; these three distinct tissues form a continuous layer within the eye. Uveitis refers to inflammation of any region of the uveal tract. Despite being grouped together anatomically, the iris, ciliary body and choroid are distinct functionally, and inflammatory diseases may affect only one part and not the others. Cellular structure of tissues direct their function, and understanding the cellular basis of the immune environment of a tissue in health, the “steady state” on which the perturbations of disease are superimposed, is vital to understanding the pathogenesis of those diseases. A contemporary understanding of the immune system accepts that haematopoietic and yolk sac derived leukocytes, though vital, are not the only players of importance. An array of stromal cells, connective tissue cells such as fibroblasts and endothelial cells, may also have a role in the inflammatory reaction seen in several immune-mediated diseases. In this review we summarise what is known about the cellular composition of the uveal tract and the roles these disparate cell types have to play in immune homeostasis. We also discuss some unanswered questions surrounding the constituents of the resident leukocyte population of the different uveal tissues, and we look ahead to the new understanding that modern investigative techniques such as single cell transcriptomics, multi-omic data integration and highly-multiplexed imaging techniques may bring to the study of the uvea and uveitis, as they already have to other immune mediated inflammatory diseases.
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影响因子：
5.1
作者：
Chen P;Denniston AK;Hirani S;Hannes S;Nussenblatt RB
通讯作者：
Nussenblatt RB
影响因子：
4.4
作者：
Birke, Kerstin;Luetjen-Drecoll, Elke;Birke, Marco T.
通讯作者：
Birke, Marco T.
影响因子：
6.4
作者：
Collin M;Bigley V
通讯作者：
Bigley V
影响因子：
6
作者：
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通讯作者：
Dick, AD
影响因子：
4.4
作者：
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通讯作者：
Wakefield, Denis