Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis.
Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis.
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DOI：
10.1155/2013/973516
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发表时间：
2013
影响因子：
--
通讯作者：
Da Poian AT
中科院分区：
文献类型：
--
作者：
Assunção-Miranda I;Cruz-Oliveira C;Da Poian AT
关节源性甲病毒，包括罗斯河病毒（RRV）、基孔肯雅病毒（CHIKV）、辛德比斯病毒（SINV）、马亚罗病毒（MAYV）、欧永-尼永病毒（ONNV）和巴尔马森林病毒（BFV），可导致丧失能力和长期持续的关节疾病/肌痛。病毒性关节炎的爆发和这些疾病的全球分布表明，关节炎源性甲病毒已成为一个重要的公共卫生问题。本文综述了甲病毒诱导关节炎的分子机制，探讨了最近在体外系统和动物模型及患者样本的体内研究中获得的数据。强调了与症状延长和持续相关的因素，重点是(a)病毒在靶细胞和组织（包括巨噬细胞和肌肉细胞）中的复制；(b)巨噬细胞、NK细胞和T淋巴细胞对病变病灶的募集和激活以及炎症介质水平的增加的炎症和免疫反应；(c)病毒或病毒产物在关节和肌肉组织中的持久性。我们还讨论了建立新的动物模型来测试新的分子靶点和开发更有效和选择性的药物来治疗这些疾病的重要性。
Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), and Barmah Forest virus (BFV), cause incapacitating and long lasting articular disease/myalgia. Outbreaks of viral arthritis and the global distribution of these diseases point to the emergence of arthritogenic alphaviruses as an important public health problem. This review discusses the molecular mechanisms involved in alphavirus-induced arthritis, exploring the recent data obtained with in vitro systems and in vivo studies using animal models and samples from patients. The factors associated to the extension and persistence of symptoms are highlighted, focusing on (a) virus replication in target cells, and tissues, including macrophages and muscle cells; (b) the inflammatory and immune responses with recruitment and activation of macrophage, NK cells and T lymphocytes to the lesion focus and the increase of inflammatory mediators levels; and (c) the persistence of virus or viral products in joint and muscle tissues. We also discuss the importance of the establishment of novel animal models to test new molecular targets and to develop more efficient and selective drugs to treat these diseases.
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DOI：
10.1093/infdis/jiq042
发表时间：
2011-01-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chow A;Her Z;Ong EK;Chen JM;Dimatatac F;Kwek DJ;Barkham T;Yang H;Rénia L;Leo YS;Ng LF
通讯作者：
Ng LF
影响因子：
3.7
作者：
Burke, Crystal W.;Gardner, Christina L.;Steffan, Joshua J.;Ryman, Kate D.;Klimstra, William B.
通讯作者：
Klimstra, William B.
影响因子：
6.7
作者：
Gunn BM;Morrison TE;Whitmore AC;Blevins LK;Hueston L;Fraser RJ;Herrero LJ;Ramirez R;Smith PN;Mahalingam S;Heise MT
通讯作者：
Heise MT
DOI：
10.1111/j.1445-5994.1981.tb04226.x
发表时间：
1981-01-01
期刊：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE
影响因子：
--
作者：
FRASER, JRE;CUNNINGHAM, AL;LEACH, R
通讯作者：
LEACH, R
影响因子：
3.7
作者：
Gardner CL;Burke CW;Higgs ST;Klimstra WB;Ryman KD
通讯作者：
Ryman KD