Mechanical properties of suprarenal and infrarenal abdominal aorta: implications for mouse models of aneurysms.
Mechanical properties of suprarenal and infrarenal abdominal aorta: implications for mouse models of aneurysms.
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DOI：
10.1016/j.medengphy.2011.06.003
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发表时间：
2011-12
影响因子：
2.2
通讯作者：
Humphrey JD
中科院分区：
文献类型：
--
作者：
Collins MJ;Bersi M;Wilson E;Humphrey JD
已经开发了多种小鼠模型来增加我们对腹主动脉瘤自然史的了解。这种模型的优点是可以量化病变发展时几何形状、组织学、细胞生物学和力学变化的时间过程。最常用的小鼠模型之一在肾上腹主动脉产生病变，而大多数其他模型则针对肾下腹主动脉，这与临床观察结果一致，即人类几乎所有腹动脉瘤都发生在肾下主动脉。了解不同小鼠模型和人类病变之间相似性和差异性的原因可能会提供更多的见解，而单独研究单一情况是不可能的。然而，为此，我们必须首先直接比较小鼠腹主动脉这两个部分的天然结构和特性。在本文中，我们提出了小鼠肾上和肾下主动脉的第一个双轴力学数据和非线性本构描述符，尽管存在明显的形态和组织学差异，但仅揭示了细微的机械差异。这些数据有望提高我们理解和模拟这些致命病变自然史的能力。
Multiple mouse models have been developed to increase our understanding of the natural history of abdominal aortic aneurysms. An advantage of such models is that one can quantify the time course of changes in geometry, histology, cell biology, and mechanics as a lesion develops. One of the most commonly used mouse models yields lesions in the suprarenal abdominal aorta whereas most other models target the infrarenal abdominal aorta, consistent with the clinical observation that nearly all abdominal aneurysms in humans occur in the infrarenal aorta. Understanding reasons for similarities and differences between diverse mouse models and human lesions may provide increased insight that would not be possible studying a single situation alone. Toward this end, however, we must first compare directly the native structure and properties of these two portions of the abdominal aorta in the mouse. In this paper, we present the first biaxial mechanical data and nonlinear constitutive descriptors for the suprarenal and infrarenal aorta in mice, which reveals only subtle mechanical differences despite marked morphological and histological differences. Such data promise to increase our ability to understand and model the natural history of these deadly lesions.
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影响因子：
4.4
作者：
Goergen, Craig J.;Barr, Kyla N.;Huynh, Diem T.;Eastham-Anderson, Jeffrey R.;Choi, Gilwoo;Hedehus, Maj;Dalman, Ronald L.;Connolly, Andrew J.;Taylor, Charles A.;Tsao, Philip S.;Greve, Joan M.
通讯作者：
Greve, Joan M.
影响因子：
3.8
作者：
Wan, William;Yanagisawa, Hiromi;Gleason, Rudolph L., Jr.
通讯作者：
Gleason, Rudolph L., Jr.
DOI：
10.1196/annals.1383.029
发表时间：
2006-01-01
期刊：
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY
影响因子：
--
作者：
Thompson, Robert W.;Curci, John A.;Pham, Christine T. N.
通讯作者：
Pham, Christine T. N.
影响因子：
2.4
作者：
Humphrey, J. D.;Eberth, J. F.;Dye, W. W.;Gleason, R. L.
通讯作者：
Gleason, R. L.
DOI：
10.1161/01.atv.14.1.133
发表时间：
1994-01-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
NAKASHIMA, Y;PLUMP, AS;ROSS, R
通讯作者：
ROSS, R