Fundamental role of axial stress in compensatory adaptations by arteries.
Fundamental role of axial stress in compensatory adaptations by arteries.
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DOI：
10.1016/j.jbiomech.2008.11.011
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发表时间：
2009-01-05
影响因子：
2.4
通讯作者：
Gleason, R. L.
中科院分区：
文献类型：
--
作者：
Humphrey, J. D.;Eberth, J. F.;Dye, W. W.;Gleason, R. L.
动脉表现出适应各种遗传缺陷和机械负荷持续变化的非凡能力。例如，血流引起的壁剪切应力的变化倾向于控制动脉口径，而血压引起的周向壁应力的变化倾向于控制壁厚度。然而，我们认为，壁应力的轴向分量在控制动脉的几何形状、结构和功能，即代偿性适应中起着类似的基本作用。这一观察结果来自文献中报道的结果的回顾和我们实验室最近四项研究的比较，这些研究量化了细胞-基质相互作用、细胞外基质成分、血压或轴向伸展改变情况下小鼠颈动脉双轴力学性能的变化。有，因此，迫切需要包括动脉生长和重塑的概念和理论模型的轴向壁应力的基本作用，因此，有必要增加关注的情况下，改变遗传和机械刺激的双轴力学性能的发展。
Arteries exhibit a remarkable ability to adapt to diverse genetic defects and sustained alterations in mechanical loading. For example, changes in blood flow induced wall shear stress tend to control arterial caliber and changes in blood pressure induced circumferential wall stress tend to control wall thickness. We submit, however, that the axial component of wall stress plays a similarly fundamental role in controlling arterial geometry, structure, and function, that is, compensatory adaptations. This observation comes from a review of findings reported in the literature and a comparison of four recent studies from our laboratory that quantified changes in the biaxial mechanical properties of mouse carotid arteries in cases of altered cell-matrix interactions, extracellular matrix composition, blood pressure, or axial extension. There is, therefore, a pressing need to include the fundamental role of axial wall stress in conceptual and theoretical models of arterial growth and remodeling and, consequently, there is a need for increased attention to evolving biaxial mechanical properties in cases of altered genetics and mechanical stimuli.
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