In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth.
In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth.
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DOI：
10.1002/jmri.22331
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发表时间：
2010-10
影响因子：
4.4
通讯作者：
Greve, Joan M.
中科院分区：
文献类型：
--
作者：
Goergen, Craig J.;Barr, Kyla N.;Huynh, Diem T.;Eastham-Anderson, Jeffrey R.;Choi, Gilwoo;Hedehus, Maj;Dalman, Ronald L.;Connolly, Andrew J.;Taylor, Charles A.;Tsao, Philip S.;Greve, Joan M.
建立小鼠腹主动脉在体周期性应变、运动和弯曲的定量方法。对C57 BL/6 J和apoE −/−小鼠进行3D飞行时间MR血管造影术，以将心脏门控2D切片定位在腹主动脉沿着的四个位置，计算周向循环应变和管腔质心运动。根据3D数据，创建通过主动脉的中心线，以0.1 mm间隔量化几何曲率。死后用组织学定量内侧弹性蛋白含量。定性评价血管紧张素II输注产生的腹主动脉瘤（AAA）的位置和形状。所有位置和组间的应变波形相似。肾血管上方的质心运动明显大于下方（P <0.05）。最大几何曲率发生在右肾动脉近端。血管周围的弹性蛋白含量相似。AAA在与最大曲率相同的位置发展，并沿与血管曲率和运动相同的方向生长。所提出的方法提供了时间和空间分辨的数据量化小鼠体内主动脉运动和曲率。这种非侵入性方法将允许连续量化这些参数如何影响AAA生长的位置和方向。
To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo. C57BL/6J and apoE−/− mice underwent 3D time-of-flight MR angiography to position cardiac-gated 2D slices at four locations along the abdominal aorta where circumferential cyclic strain and lumen centroid motion were calculated. From the 3D data, a centerline through the aorta was created to quantify geometric curvature at 0.1mm intervals. Medial elastin content was quantified with histology post-mortem. The location and shape of abdominal aortic aneurysms (AAAs), created from angiotensin II infusion, were evaluated qualitatively. Strain waveforms were similar at all locations and between groups. Centroid motion was significantly larger and more leftward above the renal vessels than below (p<0.05). Maximum geometric curvature occurred slightly proximal to the right renal artery. Elastin content was similar around the circumference of the vessel. AAAs developed in the same location as the maximum curvature and grew in the same direction as vessel curvature and motion. The methods presented provide temporally and spatially resolved data quantifying murine aortic motion and curvature in vivo. This non-invasive methodology will allow serial quantification of how these parameters influence the location and direction of AAA growth.
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影响因子：
3.8
作者：
Choi, Gilwoo;Cheng, Christopher P.;Taylor, Charles A.
通讯作者：
Taylor, Charles A.
影响因子：
5.8
作者：
Duprez, Daniel A;Cohn, Jay N
通讯作者：
Cohn, Jay N
影响因子：
3.3
作者：
Draney, MT;Arko, FR;Taylor, CA
通讯作者：
Taylor, CA
影响因子：
4.3
作者：
Malina, M;Länne, T;Brunkwall, J
通讯作者：
Brunkwall, J
影响因子：
11.1
作者：
Li, Hong Hua;Roy, Madhuri;Kuscuoglu, Unsal;Spencer, Corinne M.;Halm, Birgit;Harrison, Katharine C.;Bayle, Joseph H.;Splendore, Alessandra;Ding, Feng;Meltzer, Leslie A.;Wright, Elena;Paylor, Richard;Deisseroth, Karl;Francke, Uta
通讯作者：
Francke, Uta