Removal of beneficial insertion effects prevent the long-term persistence of transposable elements within simulated asexual populations.

Removal of beneficial insertion effects prevent the long-term persistence of transposable elements within simulated asexual populations.
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DOI:
10.1186/s12864-021-07569-3
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发表时间:
2021-04-07
期刊:
影响因子:
4.4
通讯作者:
Taylor MI
Taylor MI
中科院分区:
生物学2区
文献类型:
--
作者:
Butler CL;Bell EA;Taylor MI

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转座因子是大多数生物基因组的重要组成部分,但其丰度在物种间差异显着的原因知之甚少。最近的一项研究表明,即使在缺乏传统分子进化解释的情况下,转座子增殖也可能通过一种称为“转座子工程”的过程发生。然而,他们的模型使用了20%的固定有益转座子插入频率,我们认为这是不切实际的高。降低这种有益的插入频率,同时保持所有其他参数相同,防止转座子增殖。我们的结论是,作者的原始发现更好地解释通过积极选择的行动,而不是“转座子工程”,有益的插入效果仍然很重要,在转座子增殖事件。
Transposable elements are significant components of most organism’s genomes, yet the reasons why their abundances vary significantly among species is poorly understood. A recent study has suggested that even in the absence of traditional molecular evolutionary explanations, transposon proliferation may occur through a process known as ‘transposon engineering’. However, their model used a fixed beneficial transposon insertion frequency of 20%, which we believe to be unrealistically high. Reducing this beneficial insertion frequency, while keeping all other parameters identical, prevented transposon proliferation. We conclude that the author’s original findings are better explained through the action of positive selection rather than ‘transposon engineering’, with beneficial insertion effects remaining important during transposon proliferation events.
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