Effect of antibodies on endothelium.
Effect of antibodies on endothelium.
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DOI：
10.1111/j.1600-6143.2009.02819.x
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Reed EF
中科院分区：
文献类型：
--
作者：
Zhang X;Reed EF
移植后产生抗移植物内皮细胞表达的HLA和非HLA抗原抗体的患者发生更频繁的排斥反应，并降低了长期移植物存活率。针对内皮的抗体可以通过几种机制改变/损害移植物的细胞。历史上，抗体被认为通过补体依赖性机制引起内皮细胞损伤。新的研究表明，抗体也可以通过刺激促炎症和促增殖信号来促进移植排斥反应的过程。抗体连接导致EC中的几种功能改变，包括Weibel Palade体胞吐、白细胞募集、生长因子表达和细胞增殖。相反，在某些情况下，抗体可以诱导促存活信号和移植物调节。调节调节与排斥的信号传导事件似乎受到抗HLA抗体的特异性和浓度以及分子聚集程度的影响。HLA和非HLA抗体介导的信号通路的知识有可能确定新的治疗靶点，以促进适应和预防急性和慢性抗体介导的排斥反应。
Patients developing posttransplant antibodies against HLA and non-HLA antigens expressed by the endothelium of the graft undergo more frequent episodes of rejection and have decreased long-term graft survival. Antibodies against the endothelium can alter/damage the cells of the graft through several mechanisms. Historically, antibodies were thought to elicit endothelial cell injury via complement-dependent mechanisms. New research has shown that antibodies can also contribute to the process of transplant rejection by stimulating proinflammatory and proproliferation signals. Antibody ligation leads to several functional alterations in EC including Weibel Palade body exocytosis, leukocyte recruitment, growth factor expression and cell proliferation. In contrast, under certain circumstances, antibodies may induce prosurvival signals and graft accommodation. The signaling events regulating accommodation vs. rejection appear to be influenced by the specificity and concentration of the anti-HLA antibody and the degree of molecular aggregation. Knowledge of the HLA and non-HLA antibody-mediated signaling pathways has the potential to identify new therapeutic targets to promote accommodation and prevent acute and chronic antibody-mediated rejection.
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DOI：
10.1083/jcb.144.6.1337
发表时间：
1999-03-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Farrelly N;Lee YJ;Oliver J;Dive C;Streuli CH
通讯作者：
Streuli CH
影响因子：
6.2
作者：
Jurcevic, S;Ainsworth, ME;Rose, ML
通讯作者：
Rose, ML
影响因子：
6.2
作者：
Jindra, Peter T.;Zhang, Xiaohai;Reed, Elaine F.
通讯作者：
Reed, Elaine F.
影响因子：
8.8
作者：
Ding, J. Wen;Zhou, T.;Chong, A. S.
通讯作者：
Chong, A. S.
影响因子：
8.8
作者：
Locke, J. E.;Magro, C. M.;Montgomery, R. A.
通讯作者：
Montgomery, R. A.