Expressions of cytokine genes during development of autoimmune sialadenitis in MRL/Ipr mice
Expressions of cytokine genes during development of autoimmune sialadenitis in MRL/Ipr mice
复制标题
MRL/Ipr小鼠自身免疫性唾液腺炎发生过程中细胞因子基因的表达
DOI：
--
复制
发表时间：
1993
影响因子：
5.4
通讯作者：
Y. Hayashi
中科院分区：
文献类型：
--
作者：
H. Hamano;I. Saito;N. Haneji;Y. Mitsuhashi;N. Miyasaka;Y. Hayashi
通过直接分析从患有自身免疫性涎腺炎的MRL/lpr小鼠的唾液腺组织获得的RNA来分析体内局部细胞因子基因表达。通过逆转录聚合酶链反应和免疫组织化学分析评估细胞因子基因的表达。在1月龄或2月龄小鼠唾液腺炎性病变发生前检测到白细胞介素1（IL-1）β和肿瘤坏死因子的表达，在3月龄MRL/lpr小鼠典型自身免疫性唾液腺炎发生时可明确检测到IL-6 mRNA的表达，并随年龄增长而上调。这些结果表明，这些炎性细胞因子基因的过表达参与了MRL/lpr小鼠唾液腺中器官定位自身免疫的发生和进展。
Local cytokine gene expression in vivo was analyzed by direct analysis of RNA obtained from salivary gland tissues of MRL/lpr mice with autoimmune sialadenitis. The expression of cytokine genes were assessed by the reverse‐transcriptase polymerase chain reaction, and by immunohistochemical analysis. The expression of interleukin‐1(IL‐1)β and tumor necrosis factor was detected before the onset of inflammatory lesions in the salivary glands of mice of 1 or 2 months of age, and IL‐6 mRNA expression was clearly detected at the time of onset of typical autoimmune sialadenitis at 3 months of age in MRL/lpr mice, and was up‐regulated with advancing age. These results suggest that the overexpression of these inflammatory cytokine genes is involved in the development and progression of organ‐localized autoimmunity in the salivary glands of MRL/lpr mice.
登录
查看更多内容
狼疮性肾炎小鼠肾脏中肿瘤坏死因子和 IL-1 β 基因表达增加。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Boswell,JM;Yui,MA;Burt,DW;Kelley,VE
通讯作者：
Kelley,VE
影响因子：
4.4
作者：
Raymond P. Donnelly;J. Levine;D. Hartwell;Gyorgy Frendl;Matthew J. Fenton;D. Beller
通讯作者：
Raymond P. Donnelly;J. Levine;D. Hartwell;Gyorgy Frendl;Matthew J. Fenton;D. Beller
影响因子：
--
作者：
FOX, RI;CARSTENS, SA;VAUGHAN, JH
通讯作者：
VAUGHAN, JH
影响因子：
--
作者：
HOFFMAN, RW;ALSPAUGH, MA;WALKER, SE
通讯作者：
WALKER, SE