Quantitative Three-dimensional Assessment of Knee Joint Space Width from Weight-bearing CT.
Quantitative Three-dimensional Assessment of Knee Joint Space Width from Weight-bearing CT.
复制标题
基于负重CT的膝关节间隙宽度的定量三维评估
作者：
骨关节炎结构病变的影像学检查传统上依赖于磁共振成像（MRI）和X线摄影。关节间隙测绘（JSM）能够从计算机断层扫描（CT）中对关节间隙宽度（JSW）进行三维（3 - D）定量测绘。
为了证明使用负重CT进行膝关节JSM的可重复性、再现性和可行性。
回顾性分析了2014年至2018年获取的两个双膝负重CT的便利样本，这些样本的 Kellgren - Lawrence放射学分级（KLG）≤2，并使用JSM生成3 - D JSW图。为了验证再现性，使用三组膝关节对新手进行培训，然后将JSM输出结果与专家结果进行比较。在第二个队列中，还对2周随访影像进行了JSM，以生成用于可重复性分析的3 - D JSW差异图。对所有膝关节（KLG = 0 - 4）进行统计参数映射，以证明三维基于表面分析的可行性。
在无放射学疾病的个体中，再现性（20人，年龄58±7岁，体重指数28±6 kg/m²，14名女性）和可重复性（9人，年龄53±6岁，26±4 kg/m²，7名女性）在胫股关节内侧中央间隙达到了小于±0.1mm的最佳性能。所有组的平均均方根变异系数值均＜5%。统计参数映射（33人，年龄57±7岁，27±6 kg/m²，23名女性）显示，KLG每增加一级，胫股关节内侧中央到后部的关节间隙显著变窄0.5mm（阈值p＜.05）。一个膝关节（KLG = 2）显示，在外侧关节间隙，3 - D JSW分布从基线到24个月的变化超过了最小可检测差异。
使用负重CT进行膝关节关节间隙测绘是可行的，它展示了三维关节间隙宽度分布与关节结构病变之间的关系。新手能够可靠地学习该技术，它可以针对疾病表型进行个性化设置，并且能够达到比所报道的X线摄影最佳性能至少好50%的最小可检测差异。
负重膝关节CT的关节间隙测绘能够提供三维关节间隙宽度的个性化定量测量，这些测量在骨关节炎中具有结构相关性，新手可学习，并且具有高度可重复性。
Imaging of structural disease in osteoarthritis has traditionally relied on MRI and radiography. Joint space mapping (JSM) can quantitatively map joint space width (JSW) in three dimensions (3-D) from CT To demonstrate reproducibility, repeatability, and feasibility of JSM at the knee using weight-bearing CT. Two convenience samples of weight-bearing CT of both knees acquired from 2014 to 2018 and radiographic Kellgren and Lawrence grade (KLG) ≤2 were analyzed retrospectively with JSM to deliver 3-D JSW maps. For reproducibility, three sets of knees were used for novice training, then JSM output was compared against an expert. JSM was also performed on 2-week follow-up imaging in the second cohort yielding 3-D JSW difference maps for repeatability. Statistical parametric mapping was performed on all knees (KLG=0-4) to show feasibility of surface-based analysis in 3-D. Reproducibility (20 individuals, 58±7 years, body mass index 28±6 kg/m2, 14 women) and repeatability (9 individuals, 53±6 years, 26±4 kg/m2, 7 women) reached best performance of less than ±0.1mm in the central medial tibiofemoral joint space for individuals without radiographic disease. Average root mean square coefficient of variation values were <5% across all groups. Statistical parametric mapping (33 individuals, 57±7 years, 27±6 kg/m2, 23 women) showed that the central-to-posterior medial joint space was significantly narrower by 0.5 mm for each increment in KLG (threshold p<.05). A single knee (KLG=2) demonstrated baseline versus 24-month change in 3-D JSW distribution beyond smallest detectable difference across the lateral joint space. Joint space mapping is feasible at the knee with weight-bearing CT, demonstrating a relationship between three-dimensional joint space width distribution and structural joint disease. It is reliably learned by novice users, can be personalized to disease phenotypes, and can achieve a smallest detectable difference at least 50% better than the reported best performance of radiography. Joint space mapping of weight-bearing knee CT can deliver personalized quantitative measurements of joint space width in three dimensions that are structurally relevant in osteoarthritis, learnable by novice users, and highly repeatable.
登录
查看更多内容
影响因子：
7
作者：
Ornetti P;Brandt K;Hellio-Le Graverand MP;Hochberg M;Hunter DJ;Kloppenburg M;Lane N;Maillefert JF;Mazzuca SA;Spector T;Utard-Wlerick G;Vignon E;Dougados M
通讯作者：
Dougados M
定量成像生物标志物：对技术绩效评估的统计方法的综述。
影响因子：
2.3
作者：
Raunig DL;McShane LM;Pennello G;Gatsonis C;Carson PL;Voyvodic JT;Wahl RL;Kurland BF;Schwarz AJ;Gönen M;Zahlmann G;Kondratovich MV;O'Donnell K;Petrick N;Cole PE;Garra B;Sullivan DC;QIBA Technical Performance Working Group
通讯作者：
QIBA Technical Performance Working Group
影响因子：
4
作者：
Bousson, V.;Lowitz, T.;Laredo, J. -D.
通讯作者：
Laredo, J. -D.
影响因子：
7
作者：
Altman, R. D.;Gold, G. E.
通讯作者：
Gold, G. E.
影响因子：
2.1
作者：
Segal, Neil A.;Bergin, John;Anderson, Donald D.
通讯作者：
Anderson, Donald D.