The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers.
The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers.
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DOI：
10.1093/cid/ciab004
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发表时间：
2021-08-02
期刊：
影响因子：
--
通讯作者：
Oxford University Hospitals Staff Testing Group
中科院分区：
文献类型：
--
作者：
Lumley SF;Wei J;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Peck LJ;Ritter TG;de Toledo Z;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Crook DW;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）免疫球蛋白G（IgG）抗体测量可用于估计暴露或感染人群的比例，并可提供有关未来感染风险的信息。以前对抗体应答持续时间的估计各不相同。我们提出了6个月的数据，从纵向血清阳性率研究的3276名英国医护人员（HCW）。获得了SARS-CoV-2抗核衣壳和抗刺突IgG的系列测量。区间删失生存分析用于研究可检测应答的持续时间。此外，贝叶斯混合线性模型用于研究抗核衣壳减弱。在阳性结果后，抗加标IgG水平保持稳定，例如，在180天时，在94%（95%可信区间[CrI] 91-96%）的HCW中。抗核衣壳IgG水平在第一次聚合酶链反应（PCR）阳性试验后24天（95%CrI 19-31）达到峰值，然后开始下降。考虑到452例抗核衣壳血清阳性HCW从其最大阳性IgG滴度起的中位数为121天，平均估计抗体半衰期为85（95% CrI 81-90）天。较高的最大观察到的抗核衣壳滴度与较长的估计抗体半衰期相关。年龄增加、亚洲种族和既往自我报告的症状与较高的最大抗核衣壳水平和年龄增加以及针对抗核衣壳半衰期较长的症状进行的阳性PCR检测独立相关。SARS-CoV-2抗核衣壳抗体在几个月内下降，在年轻人和没有症状的人中下降得更快。然而，抗加标IgG保持稳定检测。需要进行纵向研究，以跟踪抗体水平的长期持续时间及其与SARS-CoV-2再感染免疫力的关系。对452名血清反应阳性的医护人员进行的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）抗核衣壳免疫球蛋白G（IgG）滴度的连续测量表明，水平在85天内下降了一半。大多数血清反应阳性个体的抗加标IgG水平在6个月内仍然升高。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody measurements can be used to estimate the proportion of a population exposed or infected and may be informative about the risk of future infection. Previous estimates of the duration of antibody responses vary. We present 6 months of data from a longitudinal seroprevalence study of 3276 UK healthcare workers (HCWs). Serial measurements of SARS-CoV-2 anti-nucleocapsid and anti-spike IgG were obtained. Interval censored survival analysis was used to investigate the duration of detectable responses. Additionally, Bayesian mixed linear models were used to investigate anti-nucleocapsid waning. Anti-spike IgG levels remained stably detected after a positive result, for example, in 94% (95% credibility interval [CrI] 91–96%) of HCWs at 180 days. Anti-nucleocapsid IgG levels rose to a peak at 24 (95% CrI 19–31) days post first polymerase chain reaction (PCR)-positive test, before beginning to fall. Considering 452 anti-nucleocapsid seropositive HCWs over a median of 121 days from their maximum positive IgG titer, the mean estimated antibody half-life was 85 (95% CrI 81–90) days. Higher maximum observed anti-nucleocapsid titers were associated with longer estimated antibody half-lives. Increasing age, Asian ethnicity, and prior self-reported symptoms were independently associated with higher maximum anti-nucleocapsid levels and increasing age and a positive PCR test undertaken for symptoms with longer anti-nucleocapsid half-lives. SARS-CoV-2 anti-nucleocapsid antibodies wane within months and fall faster in younger adults and those without symptoms. However, anti-spike IgG remains stably detected. Ongoing longitudinal studies are required to track the long-term duration of antibody levels and their association with immunity to SARS-CoV-2 reinfection. Serially-measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-nucleocapsid immunoglobulin G (IgG) titres from 452 seropositive healthcare workers demonstrate levels fall by half in 85 days. Anti-spike IgG remains elevated in most seropositive individuals up to 6 months.
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影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
DOI：
10.1016/s1473-3099(20)30634-4
发表时间：
2020-12
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
National SARS-CoV-2 Serology Assay Evaluation Group
通讯作者：
National SARS-CoV-2 Serology Assay Evaluation Group
影响因子：
158.5
作者：
Gudbjartsson, Daniel F.;Norddahl, Gudmundur L.;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
8.8
作者：
Wellinghausen, Nele;Plonne, Dietmar;Deininger, Susanne
通讯作者：
Deininger, Susanne
影响因子：
11.1
作者：
Fafi-Kremer S;Bruel T;Madec Y;Grant R;Tondeur L;Grzelak L;Staropoli I;Anna F;Souque P;Fernandes-Pellerin S;Jolly N;Renaudat C;Ungeheuer MN;Schmidt-Mutter C;Collongues N;Bolle A;Velay A;Lefebvre N;Mielcarek M;Meyer N;Rey D;Charneau P;Hoen B;De Seze J;Schwartz O;Fontanet A
通讯作者：
Fontanet A